Date published: 2026-7-23

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METTL Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of METTL Antibodies for investigating methyltransferases in cellular processes. METTL Antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). METTL proteins are essential enzymes that catalyze RNA modifications, significantly impacting gene expression and cellular signaling pathways. RNA modifications by METTL proteins influence mRNA stability and translation regulation, making them central to normal cellular function. Alterations in METTL protein activity have been linked to various diseases, including cancer and neurodegenerative disorders. Research into METTL proteins continues to reveal potential therapeutic targets and biomarkers for disease detection and treatment. Understanding methylation mechanisms through METTL protein research advances our knowledge of fundamental biological processes. Investigating METTL proteins helps unlock new possibilities in disease treatment and prevention. Santa Cruz Biotechnology monoclonal antibodies for METTL proteins enable researchers worldwide to advance scientific understanding of cellular methylation processes and their impact on human health.

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METTL Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

METTL3 Antibody (D-9)

sc-518180mouse IgG2b κ349-479 (h)WB, IP, IF, ELISAh

new

(1)

METTL6 Antibody (F-8)

sc-515214mouse IgG1 κ85-107 (h)WB, IP, IF, ELISAm, r, h

new

(1)

METTL7B Antibody (D-2)

sc-398626mouse IgG2b κ169-244 (h)WB, IP, IF, ELISAh
2
(2)

METTL7B Antibody (E-10)

sc-515267mouse IgG2a κ177-244 (m)WB, IP, IF, ELISAm, r

new

(1)

METTL siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

METTL1 siRNA (h)

sc-96124hGene SilencingN/A0
(0)

METTL1 shRNA Plasmid (h)

sc-96124-SHhGene SilencingPuromycin0
(0)

METTL1 shRNA (h) Lentiviral Particles

sc-96124-VhGene SilencingPuromycin0
(0)

METTL1 siRNA (m)

sc-149382mGene SilencingN/A0
(0)

METTL1 shRNA Plasmid (m)

sc-149382-SHmGene SilencingPuromycin0
(0)

METTL1 shRNA (m) Lentiviral Particles

sc-149382-VmGene SilencingPuromycin0
(0)

METTL2 siRNA (m)

sc-149386mGene SilencingN/A0
(0)

METTL2 shRNA Plasmid (m)

sc-149386-SHmGene SilencingPuromycin0
(0)

METTL2 shRNA (m) Lentiviral Particles

sc-149386-VmGene SilencingPuromycin0
(0)

METTL2A siRNA (h)

sc-93701hGene SilencingN/A0
(0)

METTL2A shRNA Plasmid (h)

sc-93701-SHhGene SilencingPuromycin0
(0)

METTL2A shRNA (h) Lentiviral Particles

sc-93701-VhGene SilencingPuromycin0
(0)

METTL2B siRNA (h)

sc-89475hGene SilencingN/A0
(0)

METTL2B shRNA Plasmid (h)

sc-89475-SHhGene SilencingPuromycin0
(0)

METTL2B shRNA (h) Lentiviral Particles

sc-89475-VhGene SilencingPuromycin0
(0)

METTL3 siRNA (h)

sc-92172hGene SilencingN/A
14
(3)

METTL3 shRNA Plasmid (h)

sc-92172-SHhGene SilencingPuromycin
14
(3)

METTL3 shRNA (h) Lentiviral Particles

sc-92172-VhGene SilencingPuromycin
14
(3)

METTL3 siRNA (m)

sc-149387mGene SilencingN/A0
(0)

METTL3 shRNA Plasmid (m)

sc-149387-SHmGene SilencingPuromycin0
(0)

METTL3 shRNA (m) Lentiviral Particles

sc-149387-VmGene SilencingPuromycin0
(0)

METTL4 siRNA (h)

sc-75777hGene SilencingN/A
1
(0)

METTL4 shRNA Plasmid (h)

sc-75777-SHhGene SilencingPuromycin
1
(0)

METTL4 shRNA (h) Lentiviral Particles

sc-75777-VhGene SilencingPuromycin
1
(0)

METTL4 siRNA (m)

sc-149388mGene SilencingN/A
1
(0)

METTL4 shRNA Plasmid (m)

sc-149388-SHmGene SilencingPuromycin
1
(0)

METTL4 shRNA (m) Lentiviral Particles

sc-149388-VmGene SilencingPuromycin
1
(0)

METTL5 siRNA (h)

sc-95031hGene SilencingN/A0
(0)

METTL5 shRNA Plasmid (h)

sc-95031-SHhGene SilencingPuromycin0
(0)

METTL5 shRNA (h) Lentiviral Particles

sc-95031-VhGene SilencingPuromycin0
(0)

METTL5 siRNA (m)

sc-149389mGene SilencingN/A0
(0)

METTL5 shRNA Plasmid (m)

sc-149389-SHmGene SilencingPuromycin0
(0)

METTL5 shRNA (m) Lentiviral Particles

sc-149389-VmGene SilencingPuromycin0
(0)

METTL6 siRNA (h)

sc-77947hGene SilencingN/A0
(0)

METTL6 shRNA Plasmid (h)

sc-77947-SHhGene SilencingPuromycin0
(0)

METTL6 shRNA (h) Lentiviral Particles

sc-77947-VhGene SilencingPuromycin0
(0)

METTL6 siRNA (m)

sc-149390mGene SilencingN/A0
(0)

METTL6 shRNA Plasmid (m)

sc-149390-SHmGene SilencingPuromycin0
(0)

METTL6 shRNA (m) Lentiviral Particles

sc-149390-VmGene SilencingPuromycin0
(0)

METTL7A siRNA (h)

sc-95742hGene SilencingN/A0
(0)

METTL7A shRNA Plasmid (h)

sc-95742-SHhGene SilencingPuromycin0
(0)

METTL7A shRNA (h) Lentiviral Particles

sc-95742-VhGene SilencingPuromycin0
(0)

METTL7A siRNA (m)

sc-149391mGene SilencingN/A0
(0)

METTL7A shRNA Plasmid (m)

sc-149391-SHmGene SilencingPuromycin0
(0)

METTL7A shRNA (m) Lentiviral Particles

sc-149391-VmGene SilencingPuromycin0
(0)

METTL7B siRNA (h)

sc-96008hGene SilencingN/A0
(0)

METTL7B shRNA Plasmid (h)

sc-96008-SHhGene SilencingPuromycin0
(0)

METTL7B shRNA (h) Lentiviral Particles

sc-96008-VhGene SilencingPuromycin0
(0)

METTL7B siRNA (m)

sc-149392mGene SilencingN/A0
(0)

METTL7B shRNA Plasmid (m)

sc-149392-SHmGene SilencingPuromycin0
(0)

METTL7B shRNA (m) Lentiviral Particles

sc-149392-VmGene SilencingPuromycin0
(0)

METTL8 siRNA (h)

sc-94960hGene SilencingN/A0
(0)

METTL8 shRNA Plasmid (h)

sc-94960-SHhGene SilencingPuromycin0
(0)

METTL8 shRNA (h) Lentiviral Particles

sc-94960-VhGene SilencingPuromycin0
(0)

METTL9 siRNA (h)

sc-93499hGene SilencingN/A0
(0)

METTL9 shRNA Plasmid (h)

sc-93499-SHhGene SilencingPuromycin0
(0)

METTL9 shRNA (h) Lentiviral Particles

sc-93499-VhGene SilencingPuromycin0
(0)

METTL9 siRNA (m)

sc-149394mGene SilencingN/A0
(0)

METTL9 shRNA Plasmid (m)

sc-149394-SHmGene SilencingPuromycin0
(0)

METTL9 shRNA (m) Lentiviral Particles

sc-149394-VmGene SilencingPuromycin0
(0)

METTL10 siRNA (h)

sc-90724hGene SilencingN/A0
(0)

METTL10 shRNA Plasmid (h)

sc-90724-SHhGene SilencingPuromycin0
(0)

METTL10 shRNA (h) Lentiviral Particles

sc-90724-VhGene SilencingPuromycin0
(0)

METTL10 siRNA (m)

sc-149383mGene SilencingN/A0
(0)

METTL10 shRNA Plasmid (m)

sc-149383-SHmGene SilencingPuromycin0
(0)

METTL10 shRNA (m) Lentiviral Particles

sc-149383-VmGene SilencingPuromycin0
(0)

METTL11A siRNA (h)

sc-92868hGene SilencingN/A0
(0)

METTL11A shRNA Plasmid (h)

sc-92868-SHhGene SilencingPuromycin0
(0)

METTL11A shRNA (h) Lentiviral Particles

sc-92868-VhGene SilencingPuromycin0
(0)

METTL11A siRNA (m)

sc-149384mGene SilencingN/A0
(0)

METTL11A shRNA Plasmid (m)

sc-149384-SHmGene SilencingPuromycin0
(0)

METTL11A shRNA (m) Lentiviral Particles

sc-149384-VmGene SilencingPuromycin0
(0)

METTL11B siRNA (h)

sc-88099hGene SilencingN/A0
(0)

METTL11B shRNA Plasmid (h)

sc-88099-SHhGene SilencingPuromycin0
(0)

METTL11B shRNA (h) Lentiviral Particles

sc-88099-VhGene SilencingPuromycin0
(0)

METTL13 siRNA (h)

sc-88139hGene SilencingN/A
1
(0)

METTL13 shRNA Plasmid (h)

sc-88139-SHhGene SilencingPuromycin
1
(0)

METTL13 shRNA (h) Lentiviral Particles

sc-88139-VhGene SilencingPuromycin
1
(0)

METTL13 siRNA (m)

sc-140373mGene SilencingN/A0
(0)

METTL13 shRNA Plasmid (m)

sc-140373-SHmGene SilencingPuromycin0
(0)

METTL13 shRNA (m) Lentiviral Particles

sc-140373-VmGene SilencingPuromycin0
(0)

METTL14 siRNA (h)

sc-89054hGene SilencingN/A
3
(1)

METTL14 shRNA Plasmid (h)

sc-89054-SHhGene SilencingPuromycin
3
(1)

METTL14 shRNA (h) Lentiviral Particles

sc-89054-VhGene SilencingPuromycin
3
(1)

METTL14 siRNA (m)

sc-149457mGene SilencingN/A0
(0)

METTL14 shRNA Plasmid (m)

sc-149457-SHmGene SilencingPuromycin0
(0)

METTL14 shRNA (m) Lentiviral Particles

sc-149457-VmGene SilencingPuromycin0
(0)

METTL21A siRNA (h)

sc-94929hGene SilencingN/A
1
(0)

METTL21A shRNA Plasmid (h)

sc-94929-SHhGene SilencingPuromycin
1
(0)

METTL21A shRNA (h) Lentiviral Particles

sc-94929-VhGene SilencingPuromycin
1
(0)

METTL21A siRNA (m)

sc-108691mGene SilencingN/A0
(0)

METTL21A shRNA Plasmid (m)

sc-108691-SHmGene SilencingPuromycin0
(0)

METTL21A shRNA (m) Lentiviral Particles

sc-108691-VmGene SilencingPuromycin0
(0)

METTL21C siRNA (h)

sc-75445hGene SilencingN/A0
(0)

METTL21C shRNA Plasmid (h)

sc-75445-SHhGene SilencingPuromycin0
(0)

METTL21C shRNA (h) Lentiviral Particles

sc-75445-VhGene SilencingPuromycin0
(0)

METTL21C siRNA (m)

sc-140660mGene SilencingN/A0
(0)

METTL21C shRNA Plasmid (m)

sc-140660-SHmGene SilencingPuromycin0
(0)

METTL21C shRNA (m) Lentiviral Particles

sc-140660-VmGene SilencingPuromycin0
(0)

METTL22 siRNA (h)

sc-93163hGene SilencingN/A0
(0)

METTL22 shRNA Plasmid (h)

sc-93163-SHhGene SilencingPuromycin0
(0)

METTL22 shRNA (h) Lentiviral Particles

sc-93163-VhGene SilencingPuromycin0
(0)

METTL23 siRNA (m)

sc-108143mGene SilencingN/A0
(0)

METTL23 shRNA Plasmid (m)

sc-108143-SHmGene SilencingPuromycin0
(0)

METTL23 shRNA (m) Lentiviral Particles

sc-108143-VmGene SilencingPuromycin0
(0)

METTL24 siRNA (h)

sc-95323hGene SilencingN/A0
(0)

METTL24 shRNA Plasmid (h)

sc-95323-SHhGene SilencingPuromycin0
(0)

METTL24 shRNA (h) Lentiviral Particles

sc-95323-VhGene SilencingPuromycin0
(0)

METTL24 siRNA (m)

sc-140500mGene SilencingN/A0
(0)

METTL24 shRNA Plasmid (m)

sc-140500-SHmGene SilencingPuromycin0
(0)

METTL24 shRNA (m) Lentiviral Particles

sc-140500-VmGene SilencingPuromycin0
(0)

METTL25 siRNA (h)

sc-95983hGene SilencingN/A0
(0)

METTL25 shRNA Plasmid (h)

sc-95983-SHhGene SilencingPuromycin0
(0)

METTL25 shRNA (h) Lentiviral Particles

sc-95983-VhGene SilencingPuromycin0
(0)

METTL CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

METTL3 CRISPR/Cas9 KO Plasmid (h)

sc-404029Gene Knockouth0
(0)

METTL3 HDR Plasmid (h)

sc-404029-HDRHomology Directed Repairh0
(0)

METTL3 CRISPR/Cas9 KO Plasmid (m)

sc-425096Gene Knockoutm0
(0)

METTL3 HDR Plasmid (m)

sc-425096-HDRHomology Directed Repairm0
(0)

METTL4 CRISPR/Cas9 KO Plasmid (h)

sc-413051Gene Knockouth0
(0)

METTL4 HDR Plasmid (h)

sc-413051-HDRHomology Directed Repairh0
(0)

METTL4 CRISPR/Cas9 KO Plasmid (m)

sc-429415Gene Knockoutm0
(0)

METTL4 HDR Plasmid (m)

sc-429415-HDRHomology Directed Repairm0
(0)

METTL5 CRISPR/Cas9 KO Plasmid (h)

sc-418556Gene Knockouth0
(0)

METTL6 HDR Plasmid (h)

sc-416547-HDRHomology Directed Repairh0
(0)

METTL7A CRISPR/Cas9 KO Plasmid (h)

sc-407776Gene Knockouth0
(0)

METTL7A HDR Plasmid (h)

sc-407776-HDRHomology Directed Repairh0
(0)

METTL7B CRISPR/Cas9 KO Plasmid (h)

sc-408340Gene Knockouth0
(0)

METTL7B HDR Plasmid (h)

sc-408340-HDRHomology Directed Repairh0
(0)

METTL11A CRISPR/Cas9 KO Plasmid (h)

sc-412015Gene Knockouth0
(0)

METTL11A HDR Plasmid (h)

sc-412015-HDRHomology Directed Repairh0
(0)

METTL14 CRISPR/Cas9 KO Plasmid (h)

sc-406936Gene Knockouth0
(0)

METTL14 HDR Plasmid (h)

sc-406936-HDRHomology Directed Repairh0
(0)

METTL14 CRISPR/Cas9 KO Plasmid (m)

sc-431695Gene Knockoutm0
(0)

METTL14 HDR Plasmid (m)

sc-431695-HDRHomology Directed Repairm0
(0)

METTL CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

METTL3 Double Nickase Plasmid (h)

sc-404029-NICGene Knockouth0
(0)

METTL3 Double Nickase Plasmid (h2)

sc-404029-NIC-2Gene Knockouth0
(0)

METTL3 Double Nickase Plasmid (m)

sc-425096-NICGene Knockoutm0
(0)

METTL3 Double Nickase Plasmid (m2)

sc-425096-NIC-2Gene Knockoutm0
(0)

METTL6 Double Nickase Plasmid (h)

sc-416547-NICGene Knockouth0
(0)

METTL6 Double Nickase Plasmid (h2)

sc-416547-NIC-2Gene Knockouth0
(0)

METTL7B Double Nickase Plasmid (h)

sc-408340-NICGene Knockouth0
(0)

METTL11A Double Nickase Plasmid (h)

sc-412015-NICGene Knockouth0
(0)

METTL11A Double Nickase Plasmid (h2)

sc-412015-NIC-2Gene Knockouth0
(0)

METTL11B Double Nickase Plasmid (h)

sc-414653-NICGene Knockouth0
(0)

METTL11B Double Nickase Plasmid (h2)

sc-414653-NIC-2Gene Knockouth0
(0)

METTL14 Double Nickase Plasmid (h)

sc-406936-NICGene Knockouth0
(0)

METTL14 Double Nickase Plasmid (h2)

sc-406936-NIC-2Gene Knockouth0
(0)

METTL CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

METTL3 CRISPR Activation Plasmid (h)

sc-404029-ACTGene Activationh0
(0)

METTL3 CRISPR Activation Plasmid (h2)

sc-404029-ACT-2Gene Activationh0
(0)

METTL3 CRISPR Activation Plasmid (m)

sc-425096-ACTGene Activationm0
(0)

METTL3 CRISPR Activation Plasmid (m2)

sc-425096-ACT-2Gene Activationm0
(0)

METTL3 CRISPR Activation Plasmid (bovine)

sc-437359-ACTGene Activationbovine0
(0)

METTL3 CRISPR Activation Plasmid (bovine2)

sc-437359-ACT-2Gene Activationbovine0
(0)