Date published: 2026-6-5

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METTL Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of METTL Antibodies for investigating methyltransferases in cellular processes. METTL Antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). METTL proteins are essential enzymes that catalyze RNA modifications, significantly impacting gene expression and cellular signaling pathways. RNA modifications by METTL proteins influence mRNA stability and translation regulation, making them central to normal cellular function. Alterations in METTL protein activity have been linked to various diseases, including cancer and neurodegenerative disorders. Research into METTL proteins continues to reveal potential therapeutic targets and biomarkers for disease detection and treatment. Understanding methylation mechanisms through METTL protein research advances our knowledge of fundamental biological processes. Investigating METTL proteins helps unlock new possibilities in disease treatment and prevention. Santa Cruz Biotechnology monoclonal antibodies for METTL proteins enable researchers worldwide to advance scientific understanding of cellular methylation processes and their impact on human health.

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METTL Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

METTL3 Antibody (D-9)

sc-518180mouse IgG2b κ349-479 (h)WB, IP, IF, ELISAh

new

(1)

METTL6 Antibody (F-8)

sc-515214mouse IgG1 κ85-107 (h)WB, IP, IF, ELISAm, r, h

new

(1)

METTL7B Antibody (D-2)

sc-398626mouse IgG2b κ169-244 (h)WB, IP, IF, ELISAh
2
(2)

METTL7B Antibody (E-10)

sc-515267mouse IgG2a κ177-244 (m)WB, IP, IF, ELISAm, r

new

(1)

METTL CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

METTL3 CRISPR/Cas9 KO Plasmid (h)

sc-404029hGene KnockoutGFP
2
(0)

METTL3 HDR Plasmid (h)

sc-404029-HDRhHomology Directed RepairPuromycin
2
(0)

METTL3 Double Nickase Plasmid (h)

sc-404029-NIChGene KnockoutPuromycin
2
(0)

METTL3 Double Nickase Plasmid (h2)

sc-404029-NIC-2hGene KnockoutPuromycin
2
(0)

METTL3 CRISPR/Cas9 KO Plasmid (m)

sc-425096mGene KnockoutGFP0
(0)

METTL3 HDR Plasmid (m)

sc-425096-HDRmHomology Directed RepairPuromycin0
(0)

METTL3 Double Nickase Plasmid (m)

sc-425096-NICmGene KnockoutPuromycin0
(0)

METTL3 Double Nickase Plasmid (m2)

sc-425096-NIC-2mGene KnockoutPuromycin0
(0)

METTL4 CRISPR/Cas9 KO Plasmid (h)

sc-413051hGene KnockoutGFP0
(0)

METTL4 HDR Plasmid (h)

sc-413051-HDRhHomology Directed RepairPuromycin0
(0)

METTL4 CRISPR/Cas9 KO Plasmid (m)

sc-429415mGene KnockoutGFP
1
(0)

METTL4 HDR Plasmid (m)

sc-429415-HDRmHomology Directed RepairPuromycin
1
(0)

METTL5 CRISPR/Cas9 KO Plasmid (h)

sc-418556hGene KnockoutGFP0
(0)

METTL6 HDR Plasmid (h)

sc-416547-HDRhHomology Directed RepairPuromycin0
(0)

METTL6 Double Nickase Plasmid (h)

sc-416547-NIChGene KnockoutPuromycin0
(0)

METTL6 Double Nickase Plasmid (h2)

sc-416547-NIC-2hGene KnockoutPuromycin0
(0)

METTL7A CRISPR/Cas9 KO Plasmid (h)

sc-407776hGene KnockoutGFP0
(0)

METTL7A HDR Plasmid (h)

sc-407776-HDRhHomology Directed RepairPuromycin0
(0)

METTL7B CRISPR/Cas9 KO Plasmid (h)

sc-408340hGene KnockoutGFP0
(0)

METTL7B HDR Plasmid (h)

sc-408340-HDRhHomology Directed RepairPuromycin0
(0)

METTL7B Double Nickase Plasmid (h)

sc-408340-NIChGene KnockoutPuromycin0
(0)

METTL11A CRISPR/Cas9 KO Plasmid (h)

sc-412015hGene KnockoutGFP0
(0)

METTL11A HDR Plasmid (h)

sc-412015-HDRhHomology Directed RepairPuromycin0
(0)

METTL11A Double Nickase Plasmid (h)

sc-412015-NIChGene KnockoutPuromycin0
(0)

METTL11A Double Nickase Plasmid (h2)

sc-412015-NIC-2hGene KnockoutPuromycin0
(0)

METTL11B Double Nickase Plasmid (h)

sc-414653-NIChGene KnockoutPuromycin0
(0)

METTL11B Double Nickase Plasmid (h2)

sc-414653-NIC-2hGene KnockoutPuromycin0
(0)

METTL14 CRISPR/Cas9 KO Plasmid (h)

sc-406936hGene KnockoutGFP0
(0)

METTL14 HDR Plasmid (h)

sc-406936-HDRhHomology Directed RepairPuromycin0
(0)

METTL14 Double Nickase Plasmid (h)

sc-406936-NIChGene KnockoutPuromycin0
(0)

METTL14 Double Nickase Plasmid (h2)

sc-406936-NIC-2hGene KnockoutPuromycin0
(0)

METTL14 CRISPR/Cas9 KO Plasmid (m)

sc-431695mGene KnockoutGFP0
(0)

METTL14 HDR Plasmid (m)

sc-431695-HDRmHomology Directed RepairPuromycin0
(0)

METTL CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

METTL3 CRISPR Activation Plasmid (h)

sc-404029-ACThGene ActivationPuro, Blast, Hygro
2
(0)

METTL3 CRISPR Activation Plasmid (h2)

sc-404029-ACT-2hGene ActivationPuro, Blast, Hygro
2
(0)

METTL3 CRISPR Activation Plasmid (m)

sc-425096-ACTmGene ActivationPuro, Blast, Hygro0
(0)

METTL3 CRISPR Activation Plasmid (m2)

sc-425096-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

METTL3 CRISPR Activation Plasmid (bovine)

sc-437359-ACTbovineGene ActivationPuro, Blast, Hygro0
(0)

METTL3 CRISPR Activation Plasmid (bovine2)

sc-437359-ACT-2bovineGene ActivationPuro, Blast, Hygro0
(0)

METTL siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

METTL1 siRNA (h)

sc-96124hGene SilencingN/A0
(0)

METTL1 shRNA Plasmid (h)

sc-96124-SHhGene SilencingPuromycin0
(0)

METTL1 shRNA (h) Lentiviral Particles

sc-96124-VhGene SilencingPuromycin0
(0)

METTL1 siRNA (m)

sc-149382mGene SilencingN/A0
(0)

METTL1 shRNA Plasmid (m)

sc-149382-SHmGene SilencingPuromycin0
(0)

METTL1 shRNA (m) Lentiviral Particles

sc-149382-VmGene SilencingPuromycin0
(0)

METTL2 siRNA (m)

sc-149386mGene SilencingN/A0
(0)

METTL2 shRNA Plasmid (m)

sc-149386-SHmGene SilencingPuromycin0
(0)

METTL2 shRNA (m) Lentiviral Particles

sc-149386-VmGene SilencingPuromycin0
(0)

METTL2A siRNA (h)

sc-93701hGene SilencingN/A0
(0)

METTL2A shRNA Plasmid (h)

sc-93701-SHhGene SilencingPuromycin0
(0)

METTL2A shRNA (h) Lentiviral Particles

sc-93701-VhGene SilencingPuromycin0
(0)

METTL2B siRNA (h)

sc-89475hGene SilencingN/A0
(0)

METTL2B shRNA Plasmid (h)

sc-89475-SHhGene SilencingPuromycin0
(0)

METTL2B shRNA (h) Lentiviral Particles

sc-89475-VhGene SilencingPuromycin0
(0)

METTL3 siRNA (h)

sc-92172hGene SilencingN/A
14
(3)

METTL3 shRNA Plasmid (h)

sc-92172-SHhGene SilencingPuromycin
14
(3)

METTL3 shRNA (h) Lentiviral Particles

sc-92172-VhGene SilencingPuromycin
14
(3)

METTL3 siRNA (m)

sc-149387mGene SilencingN/A0
(0)

METTL3 shRNA Plasmid (m)

sc-149387-SHmGene SilencingPuromycin0
(0)

METTL3 shRNA (m) Lentiviral Particles

sc-149387-VmGene SilencingPuromycin0
(0)

METTL4 siRNA (h)

sc-75777hGene SilencingN/A
1
(0)

METTL4 shRNA Plasmid (h)

sc-75777-SHhGene SilencingPuromycin
1
(0)

METTL4 shRNA (h) Lentiviral Particles

sc-75777-VhGene SilencingPuromycin
1
(0)

METTL4 siRNA (m)

sc-149388mGene SilencingN/A
1
(0)

METTL4 shRNA Plasmid (m)

sc-149388-SHmGene SilencingPuromycin
1
(0)

METTL4 shRNA (m) Lentiviral Particles

sc-149388-VmGene SilencingPuromycin
1
(0)

METTL5 siRNA (h)

sc-95031hGene SilencingN/A0
(0)

METTL5 shRNA Plasmid (h)

sc-95031-SHhGene SilencingPuromycin0
(0)

METTL5 shRNA (h) Lentiviral Particles

sc-95031-VhGene SilencingPuromycin0
(0)

METTL5 siRNA (m)

sc-149389mGene SilencingN/A0
(0)

METTL5 shRNA Plasmid (m)

sc-149389-SHmGene SilencingPuromycin0
(0)

METTL5 shRNA (m) Lentiviral Particles

sc-149389-VmGene SilencingPuromycin0
(0)

METTL6 siRNA (h)

sc-77947hGene SilencingN/A0
(0)

METTL6 shRNA Plasmid (h)

sc-77947-SHhGene SilencingPuromycin0
(0)

METTL6 shRNA (h) Lentiviral Particles

sc-77947-VhGene SilencingPuromycin0
(0)

METTL6 siRNA (m)

sc-149390mGene SilencingN/A0
(0)

METTL6 shRNA Plasmid (m)

sc-149390-SHmGene SilencingPuromycin0
(0)

METTL6 shRNA (m) Lentiviral Particles

sc-149390-VmGene SilencingPuromycin0
(0)

METTL7A siRNA (h)

sc-95742hGene SilencingN/A0
(0)

METTL7A shRNA Plasmid (h)

sc-95742-SHhGene SilencingPuromycin0
(0)

METTL7A shRNA (h) Lentiviral Particles

sc-95742-VhGene SilencingPuromycin0
(0)

METTL7A siRNA (m)

sc-149391mGene SilencingN/A0
(0)

METTL7A shRNA Plasmid (m)

sc-149391-SHmGene SilencingPuromycin0
(0)

METTL7A shRNA (m) Lentiviral Particles

sc-149391-VmGene SilencingPuromycin0
(0)

METTL7B siRNA (h)

sc-96008hGene SilencingN/A0
(0)

METTL7B shRNA Plasmid (h)

sc-96008-SHhGene SilencingPuromycin0
(0)

METTL7B shRNA (h) Lentiviral Particles

sc-96008-VhGene SilencingPuromycin0
(0)

METTL7B siRNA (m)

sc-149392mGene SilencingN/A0
(0)

METTL7B shRNA Plasmid (m)

sc-149392-SHmGene SilencingPuromycin0
(0)

METTL7B shRNA (m) Lentiviral Particles

sc-149392-VmGene SilencingPuromycin0
(0)

METTL8 siRNA (h)

sc-94960hGene SilencingN/A0
(0)

METTL8 shRNA Plasmid (h)

sc-94960-SHhGene SilencingPuromycin0
(0)

METTL8 shRNA (h) Lentiviral Particles

sc-94960-VhGene SilencingPuromycin0
(0)

METTL9 siRNA (h)

sc-93499hGene SilencingN/A0
(0)

METTL9 shRNA Plasmid (h)

sc-93499-SHhGene SilencingPuromycin0
(0)

METTL9 shRNA (h) Lentiviral Particles

sc-93499-VhGene SilencingPuromycin0
(0)

METTL9 siRNA (m)

sc-149394mGene SilencingN/A0
(0)

METTL9 shRNA Plasmid (m)

sc-149394-SHmGene SilencingPuromycin0
(0)

METTL9 shRNA (m) Lentiviral Particles

sc-149394-VmGene SilencingPuromycin0
(0)

METTL10 siRNA (h)

sc-90724hGene SilencingN/A0
(0)

METTL10 shRNA Plasmid (h)

sc-90724-SHhGene SilencingPuromycin0
(0)

METTL10 shRNA (h) Lentiviral Particles

sc-90724-VhGene SilencingPuromycin0
(0)

METTL10 siRNA (m)

sc-149383mGene SilencingN/A0
(0)

METTL10 shRNA Plasmid (m)

sc-149383-SHmGene SilencingPuromycin0
(0)

METTL10 shRNA (m) Lentiviral Particles

sc-149383-VmGene SilencingPuromycin0
(0)

METTL11A siRNA (h)

sc-92868hGene SilencingN/A0
(0)

METTL11A shRNA Plasmid (h)

sc-92868-SHhGene SilencingPuromycin0
(0)

METTL11A shRNA (h) Lentiviral Particles

sc-92868-VhGene SilencingPuromycin0
(0)

METTL11A siRNA (m)

sc-149384mGene SilencingN/A0
(0)

METTL11A shRNA Plasmid (m)

sc-149384-SHmGene SilencingPuromycin0
(0)

METTL11A shRNA (m) Lentiviral Particles

sc-149384-VmGene SilencingPuromycin0
(0)

METTL11B siRNA (h)

sc-88099hGene SilencingN/A0
(0)

METTL11B shRNA Plasmid (h)

sc-88099-SHhGene SilencingPuromycin0
(0)

METTL11B shRNA (h) Lentiviral Particles

sc-88099-VhGene SilencingPuromycin0
(0)

METTL13 siRNA (h)

sc-88139hGene SilencingN/A
1
(0)

METTL13 shRNA Plasmid (h)

sc-88139-SHhGene SilencingPuromycin
1
(0)

METTL13 shRNA (h) Lentiviral Particles

sc-88139-VhGene SilencingPuromycin
1
(0)

METTL13 siRNA (m)

sc-140373mGene SilencingN/A0
(0)

METTL13 shRNA Plasmid (m)

sc-140373-SHmGene SilencingPuromycin0
(0)

METTL13 shRNA (m) Lentiviral Particles

sc-140373-VmGene SilencingPuromycin0
(0)

METTL14 siRNA (h)

sc-89054hGene SilencingN/A
3
(1)

METTL14 shRNA Plasmid (h)

sc-89054-SHhGene SilencingPuromycin
3
(1)

METTL14 shRNA (h) Lentiviral Particles

sc-89054-VhGene SilencingPuromycin
3
(1)

METTL14 siRNA (m)

sc-149457mGene SilencingN/A0
(0)

METTL14 shRNA Plasmid (m)

sc-149457-SHmGene SilencingPuromycin0
(0)

METTL14 shRNA (m) Lentiviral Particles

sc-149457-VmGene SilencingPuromycin0
(0)

METTL21A siRNA (h)

sc-94929hGene SilencingN/A
1
(0)

METTL21A shRNA Plasmid (h)

sc-94929-SHhGene SilencingPuromycin
1
(0)

METTL21A shRNA (h) Lentiviral Particles

sc-94929-VhGene SilencingPuromycin
1
(0)

METTL21A siRNA (m)

sc-108691mGene SilencingN/A0
(0)

METTL21A shRNA Plasmid (m)

sc-108691-SHmGene SilencingPuromycin0
(0)

METTL21A shRNA (m) Lentiviral Particles

sc-108691-VmGene SilencingPuromycin0
(0)

METTL21C siRNA (h)

sc-75445hGene SilencingN/A0
(0)

METTL21C shRNA Plasmid (h)

sc-75445-SHhGene SilencingPuromycin0
(0)

METTL21C shRNA (h) Lentiviral Particles

sc-75445-VhGene SilencingPuromycin0
(0)

METTL21C siRNA (m)

sc-140660mGene SilencingN/A0
(0)

METTL21C shRNA Plasmid (m)

sc-140660-SHmGene SilencingPuromycin0
(0)

METTL21C shRNA (m) Lentiviral Particles

sc-140660-VmGene SilencingPuromycin0
(0)

METTL22 siRNA (h)

sc-93163hGene SilencingN/A0
(0)

METTL22 shRNA Plasmid (h)

sc-93163-SHhGene SilencingPuromycin0
(0)

METTL22 shRNA (h) Lentiviral Particles

sc-93163-VhGene SilencingPuromycin0
(0)

METTL23 siRNA (m)

sc-108143mGene SilencingN/A0
(0)

METTL23 shRNA Plasmid (m)

sc-108143-SHmGene SilencingPuromycin0
(0)

METTL23 shRNA (m) Lentiviral Particles

sc-108143-VmGene SilencingPuromycin0
(0)

METTL24 siRNA (h)

sc-95323hGene SilencingN/A0
(0)

METTL24 shRNA Plasmid (h)

sc-95323-SHhGene SilencingPuromycin0
(0)

METTL24 shRNA (h) Lentiviral Particles

sc-95323-VhGene SilencingPuromycin0
(0)

METTL24 siRNA (m)

sc-140500mGene SilencingN/A0
(0)

METTL24 shRNA Plasmid (m)

sc-140500-SHmGene SilencingPuromycin0
(0)

METTL24 shRNA (m) Lentiviral Particles

sc-140500-VmGene SilencingPuromycin0
(0)

METTL25 siRNA (h)

sc-95983hGene SilencingN/A0
(0)

METTL25 shRNA Plasmid (h)

sc-95983-SHhGene SilencingPuromycin0
(0)

METTL25 shRNA (h) Lentiviral Particles

sc-95983-VhGene SilencingPuromycin0
(0)