Med28 Activators
Med28 Activators encompass a diverse array of chemical compounds that play pivotal roles in enhancing the functional activity of Med28 through intricate biochemical pathways. Forskolin and Rolipram, by augmenting cAMP levels and consequently activating PKA, indirectly enhance Med28's role in the mediator complex, pivotal for transcriptional regulation. This enhancement is achieved through phosphorylation of various transcription machinery components, facilitating more efficient transcriptional activation. Similarly, EGCG, through its inhibition of certain protein kinases, and LY294002, as a PI3K inhibitor, indirectly promote Med28's function. They do so by modifying the activity of transcription factors or coactivators, thereby facilitating the assembly and stability of transcription complexes involving Med28. Ionomycin and PMA, via the elevation of intracellular calcium levels and activation of PKC respectively, potentially enhance Med28's functionality in the mediator complex by influencing transcription factor activity and coactivator interactions.
Further influencing Med28's activity are compounds like U0126 and SB203580, which modulate key pathways like MAPK/ERK and p38 MAPK. These inhibitors can shift transcriptional dynamics in favor of pathways where Med28 plays a crucial role, thus enhancing its involvement in transcriptional regulation. Trichostatin A, by altering chromatin structure, and Sildenafil, through elevating cAMP/cGMP levels, further contribute to this enhancement. They achieve this by facilitating access of the mediator complex to DNA and influencing transcription factor phosphorylation, respectively. Additionally, Resveratrol, acting on protein acetylation via SIRT1 activation, and BAY 11-7082, through its inhibitory effect on NF-κB activation, modulate transcriptional dynamics. These actions potentially augment Med28's role in transcriptional regulation, highlighting the complex interplay of these activators in enhancing the functional activity of Med28 in transcriptional processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP activates PKA, which can phosphorylate various targets, indirectly enhancing Med28 function in transcriptional regulation as part of the mediator complex, by facilitating the assembly and stabilization of the complex. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, preventing cAMP breakdown. This elevation in cAMP can activate PKA, which may enhance Med28 activity by phosphorylating components of the transcription machinery, promoting more efficient transcriptional activation in which Med28 is involved. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits several protein kinases. By selectively inhibiting kinases that negatively regulate transcription factors or coactivators, EGCG can indirectly enhance Med28's role in mediating transcriptional activation by allowing more efficient assembly of transcription complexes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, it modulates downstream AKT signaling, potentially relieving negative feedback on transcription factors or coactivators. This could indirectly enhance Med28's activity in the mediator complex, facilitating transcriptional regulation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calmodulin-dependent pathways. These pathways may interact with transcriptional regulation processes in which Med28 is involved, potentially enhancing its role in the assembly and function of the mediator complex. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC). PKC activation can lead to the phosphorylation of transcriptional regulators, potentially enhancing the functional role of Med28 in the mediator complex by facilitating transcription factor activity and coactivator interactions. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 inhibits p38 MAPK. By inhibiting p38 MAPK, it may influence transcription factor activity and coactivator interactions, potentially enhancing Med28's role in transcriptional regulation by affecting the assembly and dynamics of the mediator complex. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is a histone deacetylase inhibitor. By altering the acetylation status of histones, TSA can change the chromatin structure, potentially enhancing Med28's role in transcriptional activation by facilitating access of the mediator complex to DNA. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, a NAD+-dependent deacetylase. By modulating protein acetylation, it can influence transcription factor activity and chromatin structure. This may enhance Med28's role in transcriptional regulation by affecting the mediator complex's interaction with transcription factors and chromatin. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 inhibits NF-κB activation by blocking IκBα phosphorylation. This inhibition can shift transcriptional dynamics, potentially enhancing Med28's role in transcriptional regulation by influencing the mediator complex's interaction with various transcription factors and coactivators. | ||||||