MEA-1 Activators
The chemical class termed MEA-1 Activators comprises compounds that can potentially modulate the activity or expression of the MEA-1 protein through indirect mechanisms. These chemicals target various signaling pathways and cellular processes, creating environments that can influence MEA-1. Compounds such as Forskolin, by increasing cAMP levels, can modulate signaling pathways potentially intersecting with MEA-1's functions. Rapamycin, an mTOR inhibitor, and Metformin, an AMPK activator, impact cell growth, metabolism, and mitochondrial function, which can indirectly impact MEA-1. LY294002, a PI3K inhibitor, and SB203580, a p38 MAPK inhibitor, influence cell survival, proliferation, and stress responses, potentially impacting MEA-1.
Additionally, 2-Deoxy-D-glucose, a glycolysis inhibitor, and Curcumin, known for its broad effects on cellular signaling, can alter cellular energy metabolism and stress responses, influencing MEA-1. Resveratrol's activation of SIRT1, SP600125's inhibition of JNK, and Trichostatin A's effect on the epigenetic landscape also have potential indirect impacts on MEA-1. Y-27632, a ROCK inhibitor, affects cellular architecture, which may have implications for MEA-1's function. BAY 11-7082's inhibition of NF-κB activation could influence gene expression, potentially affecting MEA-1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP can modulate signaling pathways potentially intersecting with MEA-1's function, particularly in processes where MEA-1 is a downstream effector. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, affecting cell growth and metabolism. Rapamycin's inhibition of mTOR signaling can indirectly influence MEA-1 through alterations in cellular growth and energy signaling pathways. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
An AMPK activator, influencing cellular energy metabolism. Metformin's activation of AMPK can modulate mitochondrial function and biogenesis, potentially affecting MEA-1 expression or activity as part of the mitochondrial stress response. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor, impacting the AKT pathway. The modulation of this pathway can influence MEA-1 indirectly by altering cellular survival, proliferation, and metabolism signals. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor, which can alter cellular response to stress or inflammation. By modulating p38 MAPK, SB203580 could indirectly affect MEA-1's function or expression by changing the cellular signaling milieu. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
A glycolysis inhibitor, inducing a cellular energy stress response. This can alter cellular energy metabolism, potentially influencing MEA-1 expression or activity as part of the cellular adaptation to energy stress. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Known to modulate multiple signaling pathways, including those related to cellular stress and metabolism. Curcumin's effects could indirectly influence MEA-1 by altering cellular signaling dynamics and stress responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Activates SIRT1, influencing cellular stress responses and mitochondrial function. SIRT1 activation can lead to modulation of pathways that may intersect with MEA-1's function, potentially affecting its expression or activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, part of the MAPK signaling pathways. By inhibiting JNK, SP600125 could indirectly influence MEA-1's function or expression by altering stress and inflammatory response signals. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor, affecting gene expression patterns broadly. This could indirectly influence MEA-1 by altering the epigenetic landscape of the cell. | ||||||