MDP-1 Activators
MDP-1 Activators function through a variety of pathways to enhance the activity of magnesium-dependent phosphatase 1, a phosphatase that plays a crucial role in modulating cellular phosphorylation states. Some activators work by increasing the levels of secondary messengers; for instance, certain compounds elevate intracellular cAMP, which in turn activates protein kinase A (PKA). PKA phosphorylates a set of regulatory proteins that can interact with MDP-1, consequently leading to its activation. Other activators directly inhibit the degradation of cAMP, further sustaining the activation of PKA and maintaining the phosphorylation cascade that favors MDP-1's activity. Moreover, there are activators that can increase the bioavailability of magnesium ions, a cofactor essential for the catalytic function of MDP-1, thus enhancing its enzymatic activity.
Additionally, specific inhibitors of protein phosphatases 1 and 2A disrupt the equilibrium of cellular phosphatase activities, potentially resulting in a compensatory upregulation of MDP-1 function as the cell attempts to restore balance. Certain activators employ alternative strategies, such as the inhibition of kinase signaling, which can lead to indirect activation of MDP-1 by shifting the cellular balance of phosphorylation towards dephosphorylation. Bioactive lipids and metal ionophores also play a role; by binding to their respective receptors or transporting metal ions into the cell, these activators can initiate signaling events or stabilize the structure of MDP-1, respectively, leading to its functional activation. Others can mimic the phosphorylated substrates of phosphatases, potentially inducing a conformational activation of MDP-1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can lead to the downstream activation of proteins involved in the PKC signaling pathway, including PRR23C. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as a calcium ionophore, raising intracellular calcium levels, which can activate calcium-dependent protein kinases potentially leading to the activation of PRR23C. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A non-selective inhibitor of phosphodiesterases which prevents cAMP degradation, leading to elevated cAMP and subsequent activation of PKA. PKA then phosphorylates proteins that can interact with and activate MDP-1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, can activate cAMP pathways and thereby stimulate PKA, which may result in the phosphorylation and activation of PRR23C. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Inhibits PP1 and PP2A, potentially leading to compensatory activation of MDP-1 to balance cellular phosphatase activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
A metal ionophore that can increase intracellular zinc concentration. Zinc can modulate various phosphatases, and at certain concentrations, it may enhance the activity of MDP-1 by stabilizing its active form or its interaction with substrates. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can activate nuclear retinoic acid receptors, which can regulate gene transcription and subsequent protein modification processes that include the activation of PRR23C. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cAMP analog, activates PKA which can lead to phosphorylation and activation of PRR23C within the cAMP signaling pathway. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
An inhibitor of Syk kinase, which can alter downstream signaling pathways, including those that regulate phosphatase activity. This alteration can indirectly lead to the activation of MDP-1 in response to changed signaling dynamics. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin can activate stress-activated protein kinases like JNK and p38 MAPK, which can phosphorylate and activate PRR23C as a stress response mechanism. | ||||||