Date published: 2026-2-14

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MDP-1 Activators

MDP-1 Activators function through a variety of pathways to enhance the activity of magnesium-dependent phosphatase 1, a phosphatase that plays a crucial role in modulating cellular phosphorylation states. Some activators work by increasing the levels of secondary messengers; for instance, certain compounds elevate intracellular cAMP, which in turn activates protein kinase A (PKA). PKA phosphorylates a set of regulatory proteins that can interact with MDP-1, consequently leading to its activation. Other activators directly inhibit the degradation of cAMP, further sustaining the activation of PKA and maintaining the phosphorylation cascade that favors MDP-1's activity. Moreover, there are activators that can increase the bioavailability of magnesium ions, a cofactor essential for the catalytic function of MDP-1, thus enhancing its enzymatic activity.

Additionally, specific inhibitors of protein phosphatases 1 and 2A disrupt the equilibrium of cellular phosphatase activities, potentially resulting in a compensatory upregulation of MDP-1 function as the cell attempts to restore balance. Certain activators employ alternative strategies, such as the inhibition of kinase signaling, which can lead to indirect activation of MDP-1 by shifting the cellular balance of phosphorylation towards dephosphorylation. Bioactive lipids and metal ionophores also play a role; by binding to their respective receptors or transporting metal ions into the cell, these activators can initiate signaling events or stabilize the structure of MDP-1, respectively, leading to its functional activation. Others can mimic the phosphorylated substrates of phosphatases, potentially inducing a conformational activation of MDP-1.

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Items 1 to 10 of 17 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$41.00
$132.00
$214.00
$500.00
$948.00
119
(6)

PMA activates protein kinase C (PKC), which can lead to the downstream activation of proteins involved in the PKC signaling pathway, including PRR23C.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$78.00
$270.00
80
(4)

Ionomycin acts as a calcium ionophore, raising intracellular calcium levels, which can activate calcium-dependent protein kinases potentially leading to the activation of PRR23C.

IBMX

28822-58-4sc-201188
sc-201188B
sc-201188A
200 mg
500 mg
1 g
$260.00
$350.00
$500.00
34
(1)

A non-selective inhibitor of phosphodiesterases which prevents cAMP degradation, leading to elevated cAMP and subsequent activation of PKA. PKA then phosphorylates proteins that can interact with and activate MDP-1.

Isoproterenol Hydrochloride

51-30-9sc-202188
sc-202188A
100 mg
500 mg
$28.00
$38.00
5
(0)

Isoproterenol, a beta-adrenergic agonist, can activate cAMP pathways and thereby stimulate PKA, which may result in the phosphorylation and activation of PRR23C.

Calyculin A

101932-71-2sc-24000
sc-24000A
10 µg
100 µg
$163.00
$800.00
59
(3)

Inhibits PP1 and PP2A, potentially leading to compensatory activation of MDP-1 to balance cellular phosphatase activity.

Zinc

7440-66-6sc-213177
100 g
$48.00
(0)

A metal ionophore that can increase intracellular zinc concentration. Zinc can modulate various phosphatases, and at certain concentrations, it may enhance the activity of MDP-1 by stabilizing its active form or its interaction with substrates.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid can activate nuclear retinoic acid receptors, which can regulate gene transcription and subsequent protein modification processes that include the activation of PRR23C.

Dibutyryl-cAMP

16980-89-5sc-201567
sc-201567A
sc-201567B
sc-201567C
20 mg
100 mg
500 mg
10 g
$47.00
$136.00
$492.00
$4552.00
74
(7)

A cAMP analog, activates PKA which can lead to phosphorylation and activation of PRR23C within the cAMP signaling pathway.

Piceatannol

10083-24-6sc-200610
sc-200610A
sc-200610B
1 mg
5 mg
25 mg
$51.00
$71.00
$199.00
11
(2)

An inhibitor of Syk kinase, which can alter downstream signaling pathways, including those that regulate phosphatase activity. This alteration can indirectly lead to the activation of MDP-1 in response to changed signaling dynamics.

Anisomycin

22862-76-6sc-3524
sc-3524A
5 mg
50 mg
$99.00
$259.00
36
(2)

Anisomycin can activate stress-activated protein kinases like JNK and p38 MAPK, which can phosphorylate and activate PRR23C as a stress response mechanism.