Date published: 2026-2-14

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MDP-1 Activators

MDP-1 Activators function through a variety of pathways to enhance the activity of magnesium-dependent phosphatase 1, a phosphatase that plays a crucial role in modulating cellular phosphorylation states. Some activators work by increasing the levels of secondary messengers; for instance, certain compounds elevate intracellular cAMP, which in turn activates protein kinase A (PKA). PKA phosphorylates a set of regulatory proteins that can interact with MDP-1, consequently leading to its activation. Other activators directly inhibit the degradation of cAMP, further sustaining the activation of PKA and maintaining the phosphorylation cascade that favors MDP-1's activity. Moreover, there are activators that can increase the bioavailability of magnesium ions, a cofactor essential for the catalytic function of MDP-1, thus enhancing its enzymatic activity.

Additionally, specific inhibitors of protein phosphatases 1 and 2A disrupt the equilibrium of cellular phosphatase activities, potentially resulting in a compensatory upregulation of MDP-1 function as the cell attempts to restore balance. Certain activators employ alternative strategies, such as the inhibition of kinase signaling, which can lead to indirect activation of MDP-1 by shifting the cellular balance of phosphorylation towards dephosphorylation. Bioactive lipids and metal ionophores also play a role; by binding to their respective receptors or transporting metal ions into the cell, these activators can initiate signaling events or stabilize the structure of MDP-1, respectively, leading to its functional activation. Others can mimic the phosphorylated substrates of phosphatases, potentially inducing a conformational activation of MDP-1.

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Items 11 to 17 of 17 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Cantharidin

56-25-7sc-201321
sc-201321A
25 mg
100 mg
$89.00
$279.00
6
(1)

An inhibitor of serine/threonine phosphatases, which may cause a compensatory response in cellular phosphatase activity, leading to the activation of MDP-1.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

Thapsigargin inhibits the SERCA pump, increasing intracellular calcium and potentially activating calcium-dependent kinases that can result in the activation of PRR23C.

Magnesium chloride

7786-30-3sc-255260C
sc-255260B
sc-255260
sc-255260A
10 g
25 g
100 g
500 g
$28.00
$35.00
$48.00
$125.00
2
(1)

As a cofactor, magnesium is essential for the catalytic activity of many phosphatases. Elevated levels of Mg2+ can enhance MDP-1 activity by improving its catalytic efficiency.

D-erythro-Sphingosine-1-phosphate

26993-30-6sc-201383
sc-201383D
sc-201383A
sc-201383B
sc-201383C
1 mg
2 mg
5 mg
10 mg
25 mg
$165.00
$322.00
$570.00
$907.00
$1727.00
7
(1)

Can engage its receptors leading to activation of pathways including PI3K/Akt, which can phosphorylate and activate PRR23C.

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$291.00
$530.00
$1800.00
78
(4)

Okadaic acid inhibits protein phosphatases PP1 and PP2A, which can result in increased phosphorylation levels of proteins, potentially leading to the activation of PRR23C.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$153.00
$396.00
113
(4)

A potent, non-selective inhibitor of protein kinases. By modulating the kinase/phosphatase balance, staurosporine can indirectly lead to activation of MDP-1 through altered phosphorylation states within the cell.

Bryostatin 1

83314-01-6sc-201407
10 µg
$245.00
9
(1)

Bryostatin 1 binds to and modulates PKC, which can lead to the phosphorylation and activation of downstream proteins in the PKC pathway including PRR23C.