Date published: 2025-11-24

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MCR Activators

Mineralocorticoid receptor (MCR) is a pivotal player in the regulation of electrolyte balance, blood volume, and blood pressure. As part of the nuclear receptor family, this group of transcription factors responds to a diverse range of ligands, which includes steroid hormones, thyroid hormones, and retinoids, ultimately governing gene expression. The MCR specifically, when activated, can bind to mineralocorticoids, primarily aldosterone. This binding primarily influences the kidneys, where the activation of MCR promotes sodium reabsorption and potassium excretion, playing a critical role in maintaining blood volume and pressure. Additionally, MR is found in other tissues, such as the heart, brain, and colon, indicating its multifaceted roles in the body beyond just fluid balance. The chemical class of MCR Activators is designed to boost the activity or expression of the mineralocorticoid receptor. Activators can heighten the receptor's response to its natural ligand, aldosterone, or even stimulate the receptor directly without the presence of the ligand. This amplification has profound physiological implications, especially in renal function and cardiovascular health. By modulating MCR activity, these activators provide a deeper understanding of this receptor's intricate roles in both health and disease.

SEE ALSO...

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Corticosterone

50-22-6sc-300391
sc-300391A
100 mg
500 mg
$57.00
$108.00
2
(2)

The HPA axis, which regulates corticosterone production, interacts with the melanocortin system, especially MC3R and MC4R. Chronic stress and elevated corticosterone levels might influence MC4R expression in certain brain regions. The exact effect can vary based on factors like exposure duration, tissue type, and other modulating factors.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Known to modulate gene expression through nuclear receptors; might influence MCR expression in certain cell types.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$76.00
$82.00
$367.00
36
(1)

A glucocorticoid that can have off-target effects on MCR, potentially influencing its expression.

Aldosterone

52-39-1sc-210774
sc-210774A
sc-210774B
sc-210774C
sc-210774D
sc-210774E
2 mg
5 mg
10 mg
50 mg
100 mg
250 mg
$254.00
$209.00
$311.00
$1520.00
$3014.00
$7487.00
1
(1)

Direct evidence of aldosterone affecting MCR expression is limited. However, since aldosterone release is stimulated by angiotensin II, which has shown interactions with the melanocortin system, there might be indirect effects on MCRs.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Increases intracellular cAMP levels, potentially influencing MCR expression through downstream effects on gene transcription.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

This polyphenol can modulate various signaling pathways and might indirectly affect MCR expression.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Might influence MCR expression via its broad effects on various cellular signaling pathways.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$150.00
$286.00
$479.00
$1299.00
$8299.00
$915.00
22
(1)

Known to modulate NRF2 signaling, which could indirectly affect MCR expression.

Rosiglitazone

122320-73-4sc-202795
sc-202795A
sc-202795C
sc-202795D
sc-202795B
25 mg
100 mg
500 mg
1 g
5 g
$118.00
$320.00
$622.00
$928.00
$1234.00
38
(1)

A PPARγ agonist, it might indirectly influence MCR expression in certain tissues.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Used in mood stabilization; its long-term effects might indirectly modulate MCR expression.