MCCB Inhibitors
MCCB inhibitors are a class of chemical compounds that specifically target the MCCB (Methylcrotonoyl-CoA Carboxylase Beta) protein, an enzyme involved in the mitochondrial metabolism of leucine, an essential amino acid. MCCB functions as part of the biotin-dependent enzyme complex, methylcrotonoyl-CoA carboxylase (MCC), which catalyzes a critical step in the catabolism of leucine by converting methylcrotonoyl-CoA to methylglutaconyl-CoA. This step is essential for breaking down leucine into simpler molecules that can be used for energy production and other metabolic processes. By inhibiting MCCB, these compounds interfere with the enzyme's ability to carry out this conversion, potentially disrupting the entire leucine degradation pathway and affecting cellular energy metabolism.
Inhibiting MCCB can lead to significant metabolic consequences, particularly in tissues that rely heavily on the proper breakdown of branched-chain amino acids like leucine for energy. MCCB inhibitors block the carboxylation process, which may result in the accumulation of upstream metabolites such as methylcrotonoyl-CoA, potentially leading to metabolic imbalances. The inhibition of MCCB can also affect the overall energy homeostasis of the cell, as leucine degradation plays a role in the production of intermediates that feed into the citric acid cycle, a central pathway in energy metabolism. By studying MCCB inhibitors, researchers can gain insights into the specific role of this enzyme in leucine catabolism and how its disruption affects broader metabolic processes within the mitochondria. These inhibitors offer valuable tools for investigating the regulation of amino acid metabolism and the impact of MCCB on mitochondrial function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid, through its inhibition of histone deacetylases, could lead to an increase in acetylation levels of histones associated with the MCCC2 gene, resulting in a more closed chromatin state and subsequent downregulation of MCCB expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This chemical could cause DNA demethylation of the promoter region of the MCCC2 gene, yet paradoxically lead to transcriptional silencing through the recruitment of methyl-CpG-binding domain proteins and repressive chromatin remodelers, thus decreasing MCCB expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
By binding to the DNA at the transcription initiation complex and preventing the elongation of RNA chains by RNA polymerase, Actinomycin D could inhibit the transcription of the MCCB gene specifically. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin could theoretically bind to the DNA-dependent RNA polymerase in human cells if there were cross-species reactivity, reducing MCCB gene transcription. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates into DNA, disrupting the replication machinery and transcriptional processes, which could result in decreased MCCB gene expression due to the prevention of RNA polymerase's progression along the DNA template. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
By creating cross-links within the DNA double helix, Mitomycin C could inhibit the unwinding of DNA, a critical step for transcription, thereby reducing the overall expression of the MCCB gene. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin selectively inhibits RNA polymerase II, the enzyme responsible for transcribing mRNA, which could lead to the targeted reduction of MCCB mRNA synthesis. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin stabilizes the complex between DNA and topoisomerase I during transcription, causing breaks in the DNA strand that could lead to decreased transcriptional read-through of the MCCB gene. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
By inhibiting the phosphorylation of the C-terminal domain of RNA polymerase II, DRB could prevent the transition of the polymerase into an elongation-competent form, thereby decreasing MCCB gene expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide can inhibit the transcription of a wide array of genes by preventing the binding of transcription factors to DNA, which could specifically result in the downregulation of MCCB gene expression. | ||||||