MCCB Activators
MCCC2, commonly referred to as MCCB, is an integral component of the 3-methylcrotonyl-CoA carboxylase enzyme, which plays a vital role in the catabolism of the amino acid leucine. As a heterodimeric enzyme, it functions alongside its counterpart, MCCA, in the mitochondrial matrix, where it catalyzes the carboxylation of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, an essential step in leucine degradation. The proper functioning of this enzyme is not only crucial for maintaining leucine levels within the body but also for overall energy production and metabolic balance. The expression of MCCB is a finely tuned process and may vary across different tissues, with significant levels observed in the prostate and kidney, indicating a possible higher demand for leucine catabolism in these areas. The gene encoding MCCB has been identified as a subject of interest in genetic studies due to its involvement in key metabolic pathways.
The expression of MCCB can be influenced by various non-peptidic chemical compounds, which can act as activators. Compounds such as retinoic acid might upregulate MCCC2, also known as MCCB, encodes the small subunit of the 3-methylcrotonyl-CoA carboxylase enzyme, pivotal in the metabolic pathway of leucine, an essential amino acid. This enzyme's function is critical for the conversion of leucine to its downstream metabolites, facilitating the body's use of this amino acid for energy generation. The expression of MCCB is ubiquitous, with notably higher expression in tissues like the prostate and kidney, hinting at a tissue-specific demand for its enzymatic activity. The gene's evolutionary conservation across species underscores its importance in cellular metabolism. MCCB expression level is tightly regulated at the transcriptional level, ensuring that the enzyme is produced in accordance with the metabolic requirements of the cell. The intricacies of this regulation are an area of active research, seeking to understand how cellular needs dictate MCCB synthesis and how this synthesis is adjusted in response to internal and external stimuli.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may upregulate MCCB by binding to retinoid receptors that interact with promoter regions of genes involved in leucine catabolism. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Clofibrate could potentially stimulate the transcription of MCCB by activating PPARs, which play a key role in lipid metabolism and may cross-talk with amino acid degradation pathways. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate may enhance MCCB expression through PPARα activation, which is known to play a role in the catabolic regulation of various metabolic processes, including those related to leucine. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone might elevate MCCB levels by acting on glucocorticoid receptors, which could initiate a cascade of events leading to increased expression of enzymes in catabolic pathways. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin could promote MCCB expression to manage energy requirements during increased metabolic demands, thereby ensuring efficient leucine utilization. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin has the potential to boost MCCB expression via activation of AMPK, which is a key sensor of cellular energy status and can upregulate energy-producing metabolic pathways. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone might induce the transcription of MCCB through its agonistic effect on PPARγ, which is implicated in the transcriptional control of genes governing fatty acid and amino acid metabolism. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol could initiate an upsurge in MCCB expression through its action on sirtuin pathways, which are connected to the regulation of mitochondrial function and energy metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin might stimulate MCCB expression by activating transcription factors and enzymes that are involved in the antioxidant response, which is closely tied to metabolic processing pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate could provoke an increase in MCCB expression due to its role in modulating signaling pathways that govern cellular metabolism and could have a secondary role in amino acid catabolism. | ||||||