MC2-R Activators
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adrenocorticotropic Hormone Fragment 1-24 human, rat | 16960-16-0 | sc-278882 sc-278882A | 250 µg 1 mg | $83.00 $239.00 | ||
Adrenocorticotropic Hormone Fragment 1-24 human, rat, acts as a potent agonist at the MC2-R receptor, facilitating the activation of adenylate cyclase and subsequent cAMP production. This fragment's specific amino acid sequence enhances its binding affinity, promoting receptor dimerization and influencing downstream signaling pathways. Its rapid kinetics of interaction and ability to modulate steroidogenesis highlight its role in regulating adrenal function and stress response mechanisms. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels, which can modulate signaling pathways intersecting with MC2R's function, potentially enhancing its activity by mimicking effects similar to ACTH. | ||||||
Adrenocorticotropic Hormone (1-39), human | 12279-41-3 | sc-396454 sc-396454A | 1 mg 5 mg | $349.00 $1313.00 | ||
Adrenocorticotropic Hormone (1-39) exhibits a unique interaction profile with the MC2-R receptor, characterized by its extended peptide sequence that enhances receptor affinity and specificity. This hormone initiates a cascade of intracellular signaling by activating G-proteins, leading to increased cAMP levels. Its structural conformation allows for effective receptor coupling, influencing gene expression related to adrenal steroid production. The hormone's dynamic binding kinetics contribute to its regulatory role in endocrine signaling pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, elevates intracellular cAMP levels, potentially enhancing MC2R signaling by mimicking ACTH-like effects. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $97.00 $144.00 $648.00 | 47 | |
A selective inhibitor of Protein Kinase A (PKA), which can modulate downstream effects of cAMP, potentially influencing MC2R signaling indirectly by affecting pathways that intersect with ACTH signaling. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Inhibits Phosphodiesterase 4, leading to increased cAMP levels, potentially enhancing MC2R signaling by creating an environment that mimics ACTH stimulation. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
An adenylate cyclase inhibitor, which can indirectly influence MC2R activity by modulating the cAMP pathway, potentially affecting the overall signaling dynamics related to MC2R. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $162.00 $683.00 | 7 | |
A phosphodiesterase 3 inhibitor, which increases cAMP levels, potentially influencing MC2R activity by altering the signaling landscape in a manner that mimics ACTH effects. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $90.00 $350.00 | 16 | |
Another phosphodiesterase 3 inhibitor, potentially enhancing MC2R signaling through increased cAMP levels, mimicking effects similar to those of ACTH. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
A phosphodiesterase 5 inhibitor, increasing cAMP and cGMP levels, which can indirectly influence MC2R signaling by altering the cellular environment in a way that enhances responses similar to ACTH. | ||||||