Molecular structure of Adrenocorticotropic Hormone (1-39), human
Adrenocorticotropic Hormone (1-39), human (CAS 12279-41-3)
Alternate Names:
ACTH (1-39); Adrenocorticotropic hormone fragment 1-39; Corticotropin A
Application:
Adrenocorticotropic Hormone (1-39), human is an MC2-R activator
CAS Number:
12279-41-3
Molecular Weight:
4541.07
Molecular Formula:
C207H308N56O58S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Adrenocorticotropic Hormone (1-39), human is a potent endogenous MC2-R (melanocortin receptor 2, MC2) agonist (EC50 = 57 pM). Component of the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid production and release from the adrenal cortex. Induces insulin resistance, promotes a proinflammatory profile and stimulates UCP-1 in adipocytes in vitro.
Adrenocorticotropic Hormone (1-39), human (CAS 12279-41-3) References
- About the use and misuse of an ACTH 1-39 radioimmunoassay to measure ACTH 1-24. | Grino, M., et al. 1999. J Clin Endocrinol Metab. 84: 824-5. PMID: 10022466
- David and Goliath - the slingshot that started the neuropeptide revolution. | Strand, FL. 2000. Eur J Pharmacol. 405: 3-12. PMID: 11033309
- Structure-activity relationships of monomeric and dimeric synthetic ACTH fragments in perifused frog adrenal slices. | Feuilloley, M., et al. 1990. J Steroid Biochem. 35: 583-92. PMID: 2162451
- Characterisation of monoclonal antibodies to adrenocorticotrophin. | White, A., et al. 1985. J Immunol Methods. 79: 185-94. PMID: 2582058
- Clinical evaluation of a two-site immunoradiometric assay for adrenocorticotrophin in unextracted human plasma using monoclonal antibodies. | White, A., et al. 1987. Clin Endocrinol (Oxf). 26: 41-51. PMID: 3026691
- Insulin releasing effects of adrenocorticotropin (ACTH 1-39) and ACTH fragments (1-24 and 18-39) in lean and genetically obese hyperglycaemic (ob/ob) mice. | Bailey, CJ. and Flatt, PR. 1987. Int J Obes. 11: 175-81. PMID: 3038765
- Long acting porcine sequence ACTH in the diagnosis of adrenal insufficiency. | Nair, A., et al. 2019. Eur J Endocrinol. 181: 639-645. PMID: 31614334
- Comparative trial with highly purified natural ACTH, synthetic ACTH 1-24 peptide and synthetic ACTH 1-39 peptide. | Brombacher, PJ., et al. 1969. Z Klin Chem Klin Biochem. 7: 291-2. PMID: 4311397
- Histological and histochemical observations on the testis and epididymis of the albino rat treated with ACTH 1-39 and dexamethasone. | Pellegrini, A. and Ricciardi, MP. 1983. Int J Tissue React. 5: 41-5. PMID: 6305865
- Proteolytic cleavage of ACTH in corticotropes of sexually mature axolotls (Ambystoma mexicanum). | Dores, RM., et al. 1993. Peptides. 14: 1029-35. PMID: 8284252
- Regulation of bioactive and immunoreactive ACTH secretion by CRF and AVP in sheep fetuses. | Zehnder, TJ., et al. 1995. Am J Physiol. 269: E1076-82. PMID: 8572199
- Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell line. | Kapas, S., et al. 1996. Endocrinology. 137: 3291-4. PMID: 8754753
- Major pharmacological distinction of the ACTH receptor from other melanocortin receptors. | Schiöth, HB., et al. 1996. Life Sci. 59: 797-801. PMID: 8761313
Activator of:
MC2-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Adrenocorticotropic Hormone (1-39), human, 1 mg | sc-396454 | 1 mg | $349.00 | |||
Adrenocorticotropic Hormone (1-39), human, 5 mg | sc-396454A | 5 mg | $1313.00 |