MBP Inhibitors
Myelin Basic Protein (MBP) is one of the primary constituents of the myelin sheath that surrounds nerve fibers in the central nervous system (CNS). This protein plays a critical role in the formation, stabilization, and maintenance of the myelin sheath, ensuring the proper insulation of nerve fibers and facilitating rapid signal transmission. The myelin sheath is a multi-layered membrane structure, and MBP acts to adhere these layers together, providing structural integrity. The protein's importance is underscored by the fact that disruptions in MBP or the myelin sheath can lead to various neurological disorders, as the integrity and function of the neural pathways become compromised. In essence, MBP is indispensable for the optimal functioning of the CNS.
MBP inhibitors are a class of chemical compounds designed to target and modulate the activity or expression of MBP. These inhibitors might function by directly binding to MBP, preventing its interaction with other components of the myelin sheath or altering its conformation. Some inhibitors could interfere with the synthesis or post-translational modifications of MBP, impacting its structure, stability, or function. Others might influence the signaling pathways that regulate MBP expression or its incorporation into the myelin sheath.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid found in fruits and vegetables, has shown to down-regulate MBP expression by modulating intracellular signaling cascades that affect MBP transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, found in turmeric, can decrease MBP levels by exerting anti-inflammatory effects and altering transcriptional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) from green tea can reduce MBP expression by modulating inflammatory responses and cellular pathways related to myelin production. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a soy isoflavone, can reduce MBP levels, potentially through its influence on estrogen receptors and downstream signaling pathways. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine has shown potential to reduce MBP levels by modulating pathways associated with inflammation and myelin synthesis. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane can modulate MBP expression potentially by exerting antioxidant and anti-inflammatory effects. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein can down-regulate MBP expression, possibly by inhibiting pathways related to inflammation and oxidative stress. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin, a plant flavone, may reduce MBP expression by modulating intracellular signaling cascades affecting MBP transcription. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol can influence MBP expression through its antioxidant and anti-inflammatory properties. | ||||||
Daidzein | 486-66-8 | sc-24001 sc-24001A sc-24001B | 100 mg 500 mg 5 g | $28.00 $79.00 $165.00 | 32 | |
Daidzein, an isoflavone, might decrease MBP levels potentially through its action on estrogen receptors and related pathways. | ||||||