MATP Inhibitors
MATP inhibitors are chemical compounds that specifically target and inhibit the activity of the membrane-associated transporter protein (MATP), also known as SLC45A2. MATP plays a significant role in the transport of ions, such as protons, across intracellular membranes, and is particularly known for its involvement in melanogenesis, the process by which pigment is produced in specialized cells called melanocytes. By inhibiting MATP, these compounds interfere with the transport processes that are crucial for proper pigment synthesis, leading to alterations in melanin production. MATP is integral to maintaining the acidic environment within melanosomes, the organelles responsible for producing and storing melanin, and inhibitors of MATP can disrupt this balance, providing insights into its role in cellular processes.
Researchers use MATP inhibitors to explore the intricate mechanisms of ion transport within cells and its broader implications on processes like pigmentation and cellular metabolism. These inhibitors allow for the study of how MATP influences the pH regulation within organelles such as melanosomes, which can affect the activity of enzymes involved in melanin biosynthesis. By blocking MATP, scientists can observe changes in melanosome function and other cellular processes that rely on the proper ion balance. MATP inhibitors serve as valuable tools for investigating how the disruption of intracellular ion transport impacts cellular homeostasis, protein function, and the biochemical pathways dependent on MATP activity. This research contributes to a deeper understanding of the molecular mechanisms governing transport proteins and their role in maintaining specialized cellular environments.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may downregulate MATP expression by inhibiting histone deacetylase, leading to a condensed chromatin state that is less permissive for gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine could directly interfere with DNA methylation processes, leading to a decrease in MATP gene transcription by disrupting the normal epigenetic marking necessary for its expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid (Vorinostat) may decrease MATP expression by preventing histone deacetylases from reverting acetylated lysine residues on histone proteins, which is necessary for maintaining the open chromatin configuration that promotes gene transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may downregulate MATP by activating sirtuin pathways that lead to the deacetylation of histones associated with the MATP gene, resulting in tighter chromatin and reduced transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin could decrease the transcriptional activity of MATP by inhibiting nuclear factor-kappa B (NF-κB), a transcription factor that may be essential for the expression of the MATP gene. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate may reduce MATP expression by serving as a histone deacetylase inhibitor, altering the acetylation state of histones near the MATP locus, thus preventing access of transcription machinery. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid may downregulate MATP expression by binding to retinoic acid receptors that interact with promoter regions of genes, potentially repressing transcription initiation of MATP. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea could inhibit MATP expression by disrupting the synthesis of deoxyribonucleotides, thereby limiting DNA replication necessary for gene transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate might reduce the expression of MATP by inhibiting DNA methyltransferases, which could lead to hypermethylation of the MATP gene promoter, resulting in transcriptional silencing. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein could reduce MATP expression by inhibiting tyrosine kinases, which may be involved in signal transduction pathways that upregulate MATP transcription. | ||||||