MATP Antibody (F-4): sc-377397

MATP Antibody (F-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects MATP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MATP Antibody (F-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The membrane-associated transporter protein (MATP) is a crucial 530 amino acid protein that traverses the lipid bilayer 12 times, playing a significant role in melanocyte differentiation. MATP is expressed at high levels in melanoma cell lines, indicating potential involvement in skin cancer development. MATP expression is regulated by microphthalmia-associated transcription factor (MITF), which is specific to melanocytes and may influence MATP transcription either directly or through remote regulatory sequences. Mutations in MATP have been associated with albinism, highlighting MATP′s critical function in pigmentation. MATP′s ability to interact with specific proteins involved in melanocyte function and skin cancer progression makes anti-MATP antibody (F-4) an essential tool for researchers studying these pathways.

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MATP Antibody (F-4) References:

1. The oculocutaneous albinism type IV gene Matp is a new marker of pigment cell precursors during mouse embryonic development.  |  Baxter, LL. and Pavan, WJ. 2002. Mech Dev. 116: 209-12. PMID: 12128226
2. Mutations in the MATP gene in five German patients affected by oculocutaneous albinism type 4.  |  Rundshagen, U., et al. 2004. Hum Mutat. 23: 106-110. PMID: 14722913
3. MATP polymorphisms in Germans and Japanese: the L374F mutation as a population marker for Caucasoids.  |  Yuasa, I., et al. 2004. Int J Legal Med. 118: 364-6. PMID: 15455243
4. A Korean case of oculocutaneous albinism type IV caused by a D157N mutation in the MATP gene.  |  Suzuki, T., et al. 2005. Br J Dermatol. 152: 174-5. PMID: 15656822
5. The immune system as the sixth sense.  |  Blalock, JE. 2005. J Intern Med. 257: 126-38. PMID: 15656872
6. Single nucleotide polymorphisms in the MATP gene are associated with normal human pigmentation variation.  |  Graf, J., et al. 2005. Hum Mutat. 25: 278-84. PMID: 15714523
7. OCA4: evidence for a founder effect for the p.D157N mutation of the MATP gene in Japanese and Korean.  |  Inagaki, K., et al. 2005. Pigment Cell Res. 18: 385-8. PMID: 16162179

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MATP Antibody (F-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-MATP Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MATP Antibody (F-4) Specifications

Alternate Product Name: MATP

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 111-240

Epitope Target: MATP

Epitope Species: human

Product Reactivity/Detection: MATP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for MATP Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin