MAST3 Inhibitors
Chemical inhibitors of MAST3 can affect the kinase's function through various mechanisms, primarily by disrupting the activity of MAST3 itself or the signaling pathways that regulate MAST3 activity. Staurosporine serves as a non-selective inhibitor, targeting a wide range of kinases including serine/threonine kinases to which MAST3 belongs. This broad-spectrum inhibition can prevent MAST3 from phosphorylating its substrates. Similarly, Bisindolylmaleimide I, by inhibiting protein kinase C, can disrupt PKC-mediated pathways that are critical for MAST3 activation. H-89, as a specific inhibitor of protein kinase A, can reduce phosphorylation and consequent activation of MAST3 by limiting PKA activity. Another inhibitor, SP600125, targets c-Jun N-terminal kinase, potentially preventing JNK-mediated phosphorylation events important for MAST3's activation. LY294002 and Wortmannin, both inhibitors of phosphoinositide 3-kinases, can also lead to decreased activation of MAST3 due to their role in PI3K-related signaling.
In addition to these, PD98059 and U0126 specifically inhibit MEK1/2, which is upstream of MAST3. By blocking MEK1/2, these inhibitors can reduce the activation of downstream kinases, including MAST3. SB203580, which selectively inhibits p38 MAP kinase, can also diminish the activation of MAST3 by interfering with related signaling pathways. PP2, as an inhibitor of Src family tyrosine kinases, can modulate the activity of serine/threonine kinases like MAST3 despite its primary target being tyrosine kinases. Rapamycin, by inhibiting mTOR, can disrupt mTOR signaling pathways that regulate MAST3. Lastly, K252a is another broad-range kinase inhibitor, which, by targeting protein kinase C among others, can interfere with the functional activity of MAST3. Each of these inhibitors, through their targeted actions on either MAST3 directly or the kinases that regulate MAST3, can lead to a decrease in MAST3 kinase activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent, non-selective inhibitor of protein kinases. MAST3 is a serine/threonine kinase, and staurosporine's broad mechanism of action includes the inhibition of this class of kinases. By inhibiting the kinase activity of MAST3, staurosporine prevents the phosphorylation of MAST3's substrates, leading to a functional inhibition of MAST3's signaling capabilities. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I, also known as GF109203X, is a specific inhibitor of protein kinase C (PKC). Given that MAST3 interacts with kinases and phosphatases related to PKC signaling, Bisindolylmaleimide I can inhibit MAST3 by disrupting associated PKC-mediated pathways that might be necessary for MAST3's full kinase activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). As MAST3 can be part of signaling pathways involving JNK, SP600125 can inhibit MAST3 by preventing JNK-mediated phosphorylation events that may be critical for MAST3's activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). MAST3 kinase activity can be modulated by PI3K signaling pathways. Inhibition of PI3K by LY294002 can lead to a decrease in MAST3 phosphorylation and activity, thereby functionally inhibiting MAST3. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK1/2). MEK1/2 is upstream of several kinases including MAST3. Inhibition by PD98059 can reduce activation of MAST3 by interfering with upstream MEK signaling, thereby inhibiting MAST3 kinase function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. MAST3 may interact with p38 MAP kinase related signaling pathways. Inhibition of p38 by SB203580 can lead to reduced MAST3 activation and subsequent inhibition of MAST3's kinase activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K, and by inhibiting this kinase, it can affect downstream proteins that are regulated via PI3K signaling pathways, including MAST3. Consequently, inhibiting PI3K with wortmannin can lead to reduced kinase activity of MAST3. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2. By inhibiting MEK1/2, U0126 can prevent the activation of downstream kinases that are regulated by MEK, including potentially MAST3, thus functionally inhibiting MAST3's kinase activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. While MAST3 is a serine/threonine kinase, Src kinases can indirectly regulate its activity. Inhibition of Src kinases by PP2 can therefore impede signaling pathways that contribute to MAST3 activation, leading to its functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor and can inhibit MAST3 by disrupting mTOR signaling pathways which can be necessary for MAST3 activation and function. Since mTOR can regulate serine/threonine kinases, its inhibition by rapamycin can lead to functional inhibition of MAST3. | ||||||