MARCKS Inhibitors
MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) inhibitors belong to a specific chemical class of compounds that are designed to target and modulate the activity of MARCKS, a protein found in various cell types, including neurons and immune cells. These inhibitors are primarily employed in scientific research and studies to investigate the role of MARCKS in cellular processes and signaling pathways. The MARCKS protein is involved in the regulation of cytoskeletal dynamics and membrane structure through its interaction with phospholipids, specifically phosphatidylinositol 4,5-bisphosphate (PIP2). It plays a pivotal role in cell motility, membrane trafficking, and exocytosis, making it an intriguing target for understanding fundamental cellular mechanisms.
MARCKS inhibitors are typically small molecules or peptides that interfere with the phosphorylation or binding of MARCKS to PIP2, thereby modulating its function. By inhibiting MARCKS, researchers can gain insights into its precise role in various cellular processes and how it influences cell morphology, migration, and vesicle trafficking. These inhibitors are valuable tools in cell biology and neuroscience research, as they allow scientists to unravel the intricate molecular mechanisms underlying these processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PKC-412 | 120685-11-2 | sc-200691 sc-200691A | 1 mg 5 mg | $51.00 $112.00 | 10 | |
Midostaurin inhibits protein kinase C, potentially reducing phosphorylation and activity of MARCKS. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
As a potent PKC inhibitor, Staurosporine may decrease MARCKS phosphorylation and expression. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
This compound selectively inhibits PKC, possibly leading to lower MARCKS activity. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 can inhibit PKC isoforms, potentially reducing MARCKS expression. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $90.00 $240.00 | 17 | |
Ro 31-8220 is a PKC inhibitor which may also diminish MARCKS expression. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $88.00 $190.00 $500.00 $2400.00 $9200.00 $15000.00 | 2 | |
Sphingosine competes with MARCKS for PKC binding, potentially inhibiting its expression. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is known to inhibit PKC, which may decrease the phosphorylation of MARCKS. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $336.00 $1642.00 | 20 | |
Targets PKC for inhibition and may indirectly reduce MARCKS expression. | ||||||
Ruboxistaurin | 169939-94-0 | sc-507364 | 25 mg | $1080.00 | ||
As a selective inhibitor of PKCβ, it may also affect the phosphorylation state of MARCKS. | ||||||
Enzastaurin | 170364-57-5 | sc-364488 sc-364488A sc-364488B | 10 mg 50 mg 200 mg | $254.00 $600.00 $1687.00 | 3 | |
This compound inhibits PKCβ and could impact MARCKS phosphorylation and expression. | ||||||