Date published: 2025-12-21

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MARCKS Inhibitors

MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) inhibitors belong to a specific chemical class of compounds that are designed to target and modulate the activity of MARCKS, a protein found in various cell types, including neurons and immune cells. These inhibitors are primarily employed in scientific research and studies to investigate the role of MARCKS in cellular processes and signaling pathways. The MARCKS protein is involved in the regulation of cytoskeletal dynamics and membrane structure through its interaction with phospholipids, specifically phosphatidylinositol 4,5-bisphosphate (PIP2). It plays a pivotal role in cell motility, membrane trafficking, and exocytosis, making it an intriguing target for understanding fundamental cellular mechanisms.

MARCKS inhibitors are typically small molecules or peptides that interfere with the phosphorylation or binding of MARCKS to PIP2, thereby modulating its function. By inhibiting MARCKS, researchers can gain insights into its precise role in various cellular processes and how it influences cell morphology, migration, and vesicle trafficking. These inhibitors are valuable tools in cell biology and neuroscience research, as they allow scientists to unravel the intricate molecular mechanisms underlying these processes.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PKC-412

120685-11-2sc-200691
sc-200691A
1 mg
5 mg
$51.00
$112.00
10
(1)

Midostaurin inhibits protein kinase C, potentially reducing phosphorylation and activity of MARCKS.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

As a potent PKC inhibitor, Staurosporine may decrease MARCKS phosphorylation and expression.

Bisindolylmaleimide I (GF 109203X)

133052-90-1sc-24003A
sc-24003
1 mg
5 mg
$103.00
$237.00
36
(1)

This compound selectively inhibits PKC, possibly leading to lower MARCKS activity.

Gö 6983

133053-19-7sc-203432
sc-203432A
sc-203432B
1 mg
5 mg
10 mg
$103.00
$293.00
$465.00
15
(1)

Gö 6983 can inhibit PKC isoforms, potentially reducing MARCKS expression.

Ro 31-8220

138489-18-6sc-200619
sc-200619A
1 mg
5 mg
$90.00
$240.00
17
(1)

Ro 31-8220 is a PKC inhibitor which may also diminish MARCKS expression.

D-erythro-Sphingosine

123-78-4sc-3546
sc-3546A
sc-3546B
sc-3546C
sc-3546D
sc-3546E
10 mg
25 mg
100 mg
1 g
5 g
10 g
$88.00
$190.00
$500.00
$2400.00
$9200.00
$15000.00
2
(2)

Sphingosine competes with MARCKS for PKC binding, potentially inhibiting its expression.

Chelerythrine

34316-15-9sc-507380
100 mg
$540.00
(0)

Chelerythrine is known to inhibit PKC, which may decrease the phosphorylation of MARCKS.

Calphostin C

121263-19-2sc-3545
sc-3545A
100 µg
1 mg
$336.00
$1642.00
20
(1)

Targets PKC for inhibition and may indirectly reduce MARCKS expression.

Ruboxistaurin

169939-94-0sc-507364
25 mg
$1080.00
(0)

As a selective inhibitor of PKCβ, it may also affect the phosphorylation state of MARCKS.

Enzastaurin

170364-57-5sc-364488
sc-364488A
sc-364488B
10 mg
50 mg
200 mg
$254.00
$600.00
$1687.00
3
(1)

This compound inhibits PKCβ and could impact MARCKS phosphorylation and expression.