You may not log in without verifying your email address.
Please check your email (including your spam email) for the Welcome message that was sent.
PKC-412, a staurosporine derivative, has been shown to possess antiproliferative characteristics via inhibition of PKC (protein kinase C), Flk (kinase insert domain receptor), and c-kit. This compound has been shown to cause an increase in the G2/M phase of the cell cycle related to polyploidy, enhanced sensitivity to ionizing radiation, and apoptosis. Additionally, PKC-412 has been reported to inhibit Flt-3/Flk-2 tyrosine kinase which consequentially causes induced G1 arrest and apoptosis of Ba/F3 cell lines. Other experiments have noted that this agent demonstrates the ability to increase endothelial nitric oxide (NO) synthase expression and NO production in cultured human endothelial cells. PKC-412 is an inhibitor of c-Src, Cdk1, cyclin B, EGFR, Flk-1, Flt-1, PDGFR-β, PKA, PKC α, PKC β, PKC γ, PKC δ, PKC η, Fgr and Syk.
1. Fabbro, D., et al. 2000. Anticancer Drug Des. 15: 17-28. PMID: 10888033
2. Weisberg, E., et al. 2002. Cancer Cell. 1: 433-443. PMID: 12124173
3. Stone, R.M., et al. 2005. Blood. 105: 54-60. PMID: 15345597
4. Li, H., et al. 2005. Nitric Oxide. 12: 231-236. PMID: 15890550
5. Chen, J., et al. 2005. Oncogene. 24: 8259-8267. PMID: 16091734
See how others have used PKC-412. Click on the entry to view the PubMed entry .
PMID: # 28403213 Hara, Y. et al. 2017. PLoS ONE. 12: e0175514.
PMID: # 28506695 Omori, I. et al. 2017. Exp. Hematol. 52: 56-64.e4.
PMID: # 28192400 Obata, Y. et al. 2017. Oncogene. 36: 3661-3672.
PMID: # 26771236 Fox, JM. et al. 2016. Oncotarget. 7: 7268-79.
PMID: # 27543462 Sulen, A. et al. 2016. Pharmacol. Res. 113: 216-227.
PMID: # 26104663 Peng, X. et al. 2015. Leukemia. 29: 2355-65.
PMID: # 24735609 Yoshida, A. et al. 2014. Biochem. Pharmacol. 90: 16-24.
PMID: # 25493654 Obata, Y. et al. 2014. Nat Commun. 5: 5715.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.