Date published: 2026-1-8

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MAN2C1 Inhibitors

MAN2C1 inhibitors represent a specific class of chemical compounds designed to target and modulate the activity of the enzyme alpha-mannosidase 2C1 (MAN2C1), a critical enzyme in the glycosylation pathway. MAN2C1 is involved in the processing of N-linked glycans, which are essential carbohydrate structures attached to proteins during their synthesis and folding. The enzyme plays a pivotal role in the trimming and remodeling of mannose residues in glycoproteins, which is crucial for their proper folding, stability, and function. Inhibitors of MAN2C1 are thus important tools for studying the biochemical pathways involved in protein glycosylation, offering insights into the regulation of glycoprotein biosynthesis, cellular glycome composition, and the overall dynamics of cellular carbohydrate processing.The inhibition of MAN2C1 can lead to alterations in glycoprotein structure, resulting in changes in the functional properties of these proteins, including their trafficking, degradation, and interactions with other cellular components. Researchers often use MAN2C1 inhibitors to dissect the roles of specific glycan structures in various biological processes, such as cell signaling, immune response, and protein quality control mechanisms within the endoplasmic reticulum and Golgi apparatus. By understanding how MAN2C1 inhibitors affect glycan processing, scientists can gain a deeper understanding of the glycosylation machinery's complexity and its broader implications in cellular biology. This exploration can also shed light on the evolutionary significance of glycan diversity in different organisms and the role of specific glycan structures in cellular adaptation and survival.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Swainsonine

72741-87-8sc-201362
sc-201362C
sc-201362A
sc-201362D
sc-201362B
1 mg
2 mg
5 mg
10 mg
25 mg
$138.00
$251.00
$631.00
$815.00
$1832.00
6
(1)

Swainsonine (CAS 72741-87-8) is a chemical compound known to act as an inhibitor of MAN2C1, an enzyme involved in N-linked glycosylation. By inhibiting MAN2C1, Swainsonine disrupts glycoprotein processing, potentially impacting cellular functions.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid may downregulate MAN2C1 expression by binding to retinoic acid receptors, leading to the transcriptional repression of the gene responsible for MAN2C1 synthesis.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

EGCG could decrease MAN2C1 expression by inhibiting the activity of specific transcription factors responsible for the gene's transcription, resulting in lower mRNA levels for MAN2C1.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

By inhibiting DNA methyltransferases, 5-Azacytidine may cause hypomethylation of the MAN2C1 gene promoter, potentially resulting in the suppression of its expression.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin could downregulate MAN2C1 expression by suppressing the activation of NF-kB, a transcription factor known to enhance the transcription of various genes, including potentially MAN2C1.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol may decrease the expression of MAN2C1 by activating sirtuins, which can deacetylate histones associated with the MAN2C1 gene promoter, leading to a tighter chromatin structure and reduced transcription.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

Trichostatin A could inhibit MAN2C1 expression by inhibiting histone deacetylases, causing hyperacetylation of histones, which in turn can lead to the silencing of gene expression, including that of MAN2C1.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$31.00
$47.00
$84.00
$222.00
19
(3)

Sodium butyrate may inhibit MAN2C1 expression by serving as a histone deacetylase inhibitor, leading to an increase in acetylated histones and the subsequent repression of MAN2C1 transcription.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$133.00
$275.00
37
(2)

Suberoylanilide Hydroxamic Acid (Vorinostat) might inhibit MAN2C1 expression by also functioning as a histone deacetylase inhibitor, thereby inducing chromatin remodeling that silences the MAN2C1 gene.

Histone Lysine Methyltransferase Inhibitor Inhibitor

935693-62-2 (free base)sc-202651
5 mg
$151.00
4
(1)

BIX-01294 could reduce the expression of MAN2C1 by inhibiting G9a histone methyltransferase, which may alter the histone methylation status of the MAN2C1 gene, leading to transcriptional repression.