MAGE-B18 Inhibitors
MAGE-B18 inhibitors encompass a range of chemical compounds that primarily target the epigenetic regulation of gene expression. These inhibitors work by altering the acetylation state of histones, which in turn affects the chromatin structure and accessibility of transcriptional machinery to the DNA. Histone deacetylase (HDAC) inhibitors are believed to decrease the expression of MAGE-B18 by increasing the acetylation of histones. This hyperacetylated state of histones leads to a more open chromatin structure, which may not favor the expression of genes like MAGE-B18 that are typically tightly regulated and expressed in a tissue-specific manner. The alteration in the epigenetic landscape by these compounds can lead to diminished expression of MAGE-B18, thereby inhibiting its functional activity.
Alongside HDAC inhibitors, DNA methyltransferase inhibitors also play a role in the inhibition of MAGE-B18. These compounds lead to DNA hypomethylation, a process that can potentially decrease the expression of tumor-specific antigens, including MAGE-B18. The reduction in methylation levels can result in changes to the expression patterns of a wide array of genes, including those involved in cancer progression and immune evasion. By influencing the methylation status of DNA, these inhibitors can contribute to a reduced presence of MAGE-B18, potentially affecting its role in oncogenesis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Histone deacetylase inhibitor that alters chromatin structure and gene expression, potentially reducing the expression of MAGE-B18 due to changes in histone acetylation patterns. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor that leads to hypomethylation of DNA and can alter the expression of tumor-specific antigens including MAGE-B18. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Histone deacetylase inhibitor, similar to Trichostatin A, that can alter the expression of cancer-testis antigens such as MAGE-B18 by modifying chromatin accessibility. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Selective histone deacetylase inhibitor that can affect the epigenetic regulation of genes, potentially diminishing MAGE-B18 expression. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Histone deacetylase inhibitor that can change the expression of various genes, including those encoding cancer-testis antigens like MAGE-B18, through epigenetic remodeling. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
DNA methyltransferase inhibitor that may decrease the expression of genes like MAGE-B18 by inducing DNA hypomethylation. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Pan-histone deacetylase inhibitor that can broadly influence gene expression patterns, possibly lowering the levels of MAGE-B18. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Histone deacetylase inhibitor that can modify the chromatin structure and consequently affect the expression of genes such as MAGE-B18. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Histone deacetylase inhibitor that can lead to the hyperacetylation of histones, potentially influencing the expression of genes like MAGE-B18. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $62.00 $250.00 $1196.00 | ||
Histone deacetylase inhibitor that can induce alterations in gene expression, which may include the downregulation of MAGE-B18 in certain contexts. | ||||||