MAGE-B1 Inhibitors
Chemical inhibitors of MAGE-B1 function by interfering with the proper regulation of chromatin structure, which is crucial for the transcription and subsequent expression of the protein. Histone deacetylase (HDAC) inhibitors such as Trichostatin A, Vorinostat, Romidepsin, Panobinostat, Belinostat, Chidamide, Entinostat, Valproic Acid, Sodium Butyrate, AR-42, Pracinostat, and Tacedinaline are known to alter the acetylation state of histones. By increasing the level of acetylation, these inhibitors prevent the chromatin from condensing, which is a state typically associated with the suppression of gene expression. This hyperacetylated state induced by HDAC inhibitors causes a relaxed chromatin structure that may prevent the binding of specific transcription factors or other proteins that are required for the transcription of MAGE-B1. As these transcription factors are unable to bind to the promoter regions of the MAGE-B1 gene, the initiation of transcription is inhibited, leading to a decrease in the production of MAGE-B1 protein and a consequent reduction in its functionality within the cell.
Furthermore, the action of HDAC inhibitors can lead to a broad effect on gene expression, but their impact on MAGE-B1 arises from the specific requirement of tightly regulated transcription for the protein's function. The alteration in chromatin structure not only impedes the transcription of MAGE-B1 but may also affect the post-transcriptional modifications and stability of the mRNA, further reducing the synthesis of the protein. As these compounds maintain the chromatin in a state that is not conducive to MAGE-B1 expression, they effectively inhibit the functional presence of the protein. The overall result is a cellular environment in which the activity of MAGE-B1 is diminished due to the decreased availability of the active protein, thereby inhibiting the cellular processes in which MAGE-B1 is involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By inhibiting HDAC, it can lead to hyperacetylation of histones, thereby affecting the chromatin structure and potentially inhibiting the access of transcription factors necessary for the expression of MAGE-B1, resulting in its functional inhibition. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is another HDAC inhibitor that could disrupt the chromatin structure and hinder transcription factors from accessing the DNA regions coding for MAGE-B1, which would inhibit its function. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin functions similarly to other HDAC inhibitors, altering chromatin architecture and preventing transcription factors from effectively promoting MAGE-B1 expression, thereby inhibiting its function. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
As an HDAC inhibitor, Panobinostat can lead to an altered chromatin state that could inhibit the expression of MAGE-B1, resulting in a decrease in its functional activity. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $153.00 $561.00 | ||
Belinostat, by inhibiting HDAC, would affect histone acetylation levels and thus chromatin structure, potentially inhibiting the transcriptional activity necessary for MAGE-B1 function. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $61.00 $245.00 $1173.00 | ||
Chidamide is an HDAC inhibitor that can alter chromatin compaction, which may inhibit the transcription factors required for MAGE-B1 expression and its subsequent functional activity. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
Entinostat inhibits HDAC enzymes, which could lead to changes in chromatin structure and a subsequent decrease in the functional activity of MAGE-B1 by inhibiting necessary transcription factor access. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid, an HDAC inhibitor, can disrupt chromatin remodeling and subsequently inhibit the function of MAGE-B1 by reducing the expression of the necessary transcription factors. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate acts as an HDAC inhibitor, potentially leading to chromatin changes that inhibit transcription factor access required for MAGE-B1 expression and function. | ||||||
(S)-HDAC-42 | 935881-37-1 | sc-296364 sc-296364A | 1 mg 5 mg | $94.00 $409.00 | ||
AR-42, as an HDAC inhibitor, can inhibit chromatin remodeling, which may result in the inhibition of transcription factor activity necessary for MAGE-B1 expression and its functional activity. | ||||||