MAGE-A4 Activators
MAGE-A4 activators belong to a class of chemical compounds that are designed to modulate the activity of the MAGE-A4 protein. MAGE-A4, short for Melanoma Antigen Gene-A4, is a member of the MAGE (Melanoma Antigen Gene) family of proteins, which are primarily known for their aberrant expression in various cancer types, particularly in melanomas and certain types of solid tumors. The MAGE-A4 protein itself is involved in several cellular processes, although its precise functions are not yet fully understood. It is believed to play a role in cell cycle regulation, cell growth, and in immune evasion mechanisms employed by cancer cells.
MAGE-A4 activators are designed to interact with MAGE-A4 protein molecules, either by enhancing their activity or inhibiting their functions, depending on the specific goals of the research or drug development. These compounds are developed with the aim of gaining a deeper understanding of the biological roles of MAGE-A4 and its implications in cancer biology. Researchers are interested in studying these activators to elucidate the intricate mechanisms by which MAGE-A4 contributes to tumorigenesis and the progression of cancer. By exploring the effects of MAGE-A4 activators, scientists aim to uncover novel insights into the underlying molecular processes of cancer development, which could ultimately lead to the development of new cancer research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Inhibits DNA methyltransferases, leading to reduced DNA methylation and potentially upregulating MAGE-A4. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
HDAC inhibitor altering chromatin structure, possibly increasing MAGE-A4 expression. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Potent pan-HDAC inhibitor, potentially affecting MAGE-A4 expression by altering chromatin accessibility. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor that modifies chromatin structure and gene expression, possibly influencing MAGE-A4 expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Selective HDAC inhibitor, potentially modifying MAGE-A4 expression by affecting chromatin structure. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
DNA methyltransferase inhibitor, can demethylate DNA and potentially upregulate genes like MAGE-A4. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
HDAC inhibitor, can modify gene expression profiles and potentially influence MAGE-A4 expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Acts as an HDAC inhibitor and can affect gene expression, potentially including MAGE-A4. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
EZH2 inhibitor, may indirectly affect the expression of genes like MAGE-A4 by modifying epigenetic marks. | ||||||
GSK343 | 1346704-33-3 | sc-397025 sc-397025A | 5 mg 25 mg | $151.00 $461.00 | 1 | |
EZH2 inhibitor, potentially influencing the expression of genes including MAGE-A4 through epigenetic modifications. | ||||||