MafA Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR stimulates AMP-activated protein kinase (AMPK) which can affect glucose metabolism, thereby indirectly influencing MAFA's activity since MAFA is regulated by glucose levels. Enhanced AMPK activity may alter the cellular energy balance, potentially modulating the transcriptional activity of MAFA. | ||||||
STO-609 | 52029-86-4 | sc-507444 | 5 mg | $140.00 | ||
STO-609 is a selective inhibitor of calcium/calmodulin-dependent kinase kinase (CaMKK). CaMKK is upstream of AMPK. Inhibition of CaMKK by STO-609 can decrease AMPK activation, potentially altering glucose-induced MAFA transcriptional activation. | ||||||
Exendin-4 | 141758-74-9 | sc-474611 sc-474611A | 500 µg 1 mg | $146.00 $198.00 | 1 | |
Exendin-4 is an agonist of the glucagon-like peptide-1 (GLP-1) receptor, which is known to enhance insulin secretion and beta-cell proliferation. Activation of GLP-1 signaling can modulate MAFA expression as a downstream effect, influencing insulin gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid affects the differentiation status of cells and can modulate the expression of numerous genes. Its influence on cellular differentiation pathways might indirectly affect the levels and activity of MAFA in pancreatic beta cells. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is a selective inhibitor of CaMKIV; although not directly linked to MAFA, it may influence cellular calcium signaling pathways that could indirectly modulate transcription factors, including MAFA, within pancreatic cells. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Although commonly known as an mTOR inhibitor, rapamycin can affect numerous cellular processes, including protein synthesis and autophagy, which can have downstream effects on the expression and stability of transcription factors like MAFA. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
As a PPAR-gamma agonist, rosiglitazone can influence glucose metabolism and insulin sensitivity. While its primary action is on PPAR-gamma, the resultant changes in glucose homeostasis could indirectly affect MAFA's transcriptional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor which may alter the insulin signaling pathway, indirectly affecting the regulation of transcription factors involved in glucose metabolism, potentially including MAFA. | ||||||
Alloxan monohydrate | 2244-11-3 | sc-254940 | 10 g | $54.00 | ||
Alloxan selectively destroys insulin-producing beta cells in the pancreas. While not an inhibitor of MAFA per se, its action results in reduced insulin and potentially reduced MAFA activity due to the loss of the cells that predominantly express it. | ||||||
Dorsomorphin dihydrochloride | 1219168-18-9 | sc-361173 sc-361173A | 10 mg 50 mg | $186.00 $751.00 | 28 | |
Dorsomorphin inhibits BMP signaling, which is implicated in pancreatic development and function. By inhibiting this pathway, it could indirectly affect the expression and function of MAFA in beta cells. | ||||||