MAD1 Inhibitors
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Atrazine | 1912-24-9 | sc-210846 | 5 g | $165.00 | 1 | |
Atrazine interferes with the hormonal and cell division processes. It inhibits cyclin-dependent kinases (CDKs) necessary for cell cycle progression which can lead to a stabilization of the mitotic checkpoint complex, indirectly influencing MAD1's role in cell cycle arrest. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a known kinesin Eg5 inhibitor. By blocking Eg5, monastrol disrupts the formation of bipolar spindles, which can lead to the activation of the spindle assembly checkpoint, thereby potentially enhancing MAD1's checkpoint function and delaying the cell cycle. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, leading to mitotic arrest. It can augment the spindle assembly checkpoint where MAD1 plays a critical role, thus indirectly acting as a MAD1 pathway modulator by promoting its checkpoint activity. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine binds to tubulin, inhibiting microtubule formation. This destabilization of microtubules can indirectly increase the activity of the spindle assembly checkpoint, consequently increasing MAD1 activity in cell cycle arrest. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization leading to cell cycle arrest at the mitotic phase. This activates the spindle assembly checkpoint and, thus, potentially increases the involvement of MAD1 in this checkpoint activation. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, inhibiting microtubule polymerization and thereby activating the spindle assembly checkpoint. This arrest in cell cycle progression can indirectly enhance MAD1's role in checkpoint surveillance. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Purvalanol A is a selective inhibitor of CDKs. By inhibiting CDK1, it can lead to cell cycle arrest at G2/M, thereby activating spindle checkpoint proteins including MAD1 to prevent premature anaphase onset. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor that disrupts chromosome alignment and can indirectly enhance the spindle assembly checkpoint's response, potentially upregulating MAD1 activity as a part of this checkpoint mechanism. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
S-Trityl-L-cysteine is a selective inhibitor of Eg5. By inhibiting this kinesin, it causes mitotic arrest and enhances the spindle checkpoint response, which can indirectly influence the MAD1-dependent cell cycle arrest function. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $31.00 $82.00 $179.00 $306.00 $561.00 | 5 | |
Thiabendazole inhibits microtubule assembly. This leads to mitotic spindle disruption, which in turn can enhance the spindle assembly checkpoint's response, potentially involving MAD1 activation to inhibit cell progression. | ||||||