mAChR M2 Inhibitors
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Items 1 to 10 of 17 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AF-DX 384 | 118290-27-0 | sc-203498 sc-203498A | 10 mg 50 mg | $129.00 $548.00 | ||
AF-DX 384 acts as a selective antagonist of the M2 muscarinic acetylcholine receptor, characterized by its unique ability to disrupt receptor conformational states. Its structural features allow for specific hydrogen bonding and hydrophobic interactions with key amino acids, influencing receptor desensitization. The compound exhibits a distinctive kinetic profile, enabling it to modulate receptor activity with precision, thereby affecting downstream signaling cascades. | ||||||
AQ-RA 741 | 123548-16-3 | sc-203517 sc-203517A | 10 mg 50 mg | $135.00 $575.00 | ||
AQ-RA 741 functions as a modulator of the M2 muscarinic acetylcholine receptor, distinguished by its capacity to stabilize specific receptor conformations. Its unique molecular architecture facilitates intricate electrostatic interactions and steric hindrance with critical residues, impacting receptor activation dynamics. The compound's reaction kinetics reveal a nuanced binding affinity, allowing for selective engagement with the receptor's allosteric sites, thereby influencing intracellular signaling pathways. | ||||||
Atropine | 51-55-8 | sc-252392 | 5 g | $204.00 | 2 | |
Atropine, a tropane alkaloid, inhibits mAChR M2 by competitively binding to its acetylcholine binding site. This hinders acetylcholine from binding to the receptor, preventing downstream signaling. The blockade of mAChR M2 signaling leads to a reduction in parasympathetic nervous system activity. | ||||||
Biperiden hydrochloride | 1235-82-1 | sc-203846 sc-203846A | 10 mg 50 mg | $160.00 $505.00 | ||
Biperiden hydrochloride acts as a selective antagonist at the M2 muscarinic acetylcholine receptor, characterized by its ability to disrupt acetylcholine binding through competitive inhibition. Its structural features enable it to form specific hydrogen bonds and hydrophobic interactions with receptor domains, altering conformational states. This modulation affects downstream signaling cascades, showcasing its role in fine-tuning receptor activity and influencing neurotransmitter release dynamics. | ||||||
Gallamine Triethiodide | 65-29-2 | sc-200175 sc-200175A | 1 g 5 g | $145.00 $300.00 | 1 | |
Gallamine Triethiodide, a non-depolarizing neuromuscular blocking agent, indirectly inhibits mAChR M2 by blocking the action of acetylcholine at the neuromuscular junction. This results in reduced activation of mAChR M2 and subsequent inhibition of parasympathetic responses in smooth muscle. | ||||||
AF-DX 116 | 102394-31-0 | sc-223772 | 5 mg | $109.00 | 3 | |
AF-DX 116 is a selective antagonist of the M2 muscarinic acetylcholine receptor, exhibiting unique binding characteristics that enhance its specificity. Its molecular structure facilitates distinct electrostatic interactions and steric hindrance, effectively blocking acetylcholine access. This compound influences receptor conformational dynamics, leading to altered intracellular signaling pathways. The kinetics of its binding suggest a rapid onset of action, contributing to its nuanced modulation of cholinergic transmission. | ||||||
Telenzepine dihydrochloride | 147416-96-4 | sc-204332 sc-204332A | 10 mg 25 mg | $63.00 $131.00 | ||
Telenzepine dihydrochloride acts as a selective modulator of the M2 muscarinic acetylcholine receptor, characterized by its unique allosteric binding site interactions. This compound exhibits a distinctive ability to stabilize specific receptor conformations, thereby influencing downstream signaling cascades. Its reaction kinetics reveal a slow dissociation rate, allowing for prolonged receptor engagement. Additionally, Telenzepine dihydrochloride's hydrophilic nature enhances solubility, facilitating effective receptor interaction. | ||||||
PD 102807 | 23062-91-1 | sc-203659 sc-203659A | 1 mg 10 mg | $202.00 $950.00 | 2 | |
PD 102807 is a selective antagonist of the M2 muscarinic acetylcholine receptor, distinguished by its unique binding affinity that alters receptor dynamics. This compound exhibits a rapid onset of action, with kinetic profiles indicating swift receptor occupancy. Its structural features promote specific hydrogen bonding interactions, enhancing selectivity. Furthermore, PD 102807's lipophilic characteristics contribute to its membrane permeability, influencing its pharmacokinetic behavior. | ||||||
(S)-(+)-Dimethindene maleate | 121367-05-3 | sc-361329 sc-361329A | 10 mg 50 mg | $240.00 $979.00 | 1 | |
(S)-(+)-Dimethindene maleate acts as a selective modulator of the M2 muscarinic acetylcholine receptor, characterized by its unique stereochemistry that influences receptor conformation. This compound demonstrates a distinctive interaction profile, facilitating allosteric modulation that fine-tunes receptor signaling pathways. Its hydrophobic regions enhance membrane interaction, while specific electrostatic interactions promote targeted binding, affecting downstream cellular responses and receptor desensitization kinetics. | ||||||
Oxybutynin Chloride | 1508-65-2 | sc-208141 | 2.5 g | $265.00 | ||
Oxybutynin Chloride exhibits a unique affinity for the M2 muscarinic acetylcholine receptor, engaging in specific hydrogen bonding and hydrophobic interactions that stabilize its binding. This compound's structural features allow it to influence receptor dynamics, leading to altered signaling cascades. Its kinetic behavior showcases a rapid association and slower dissociation, which may impact receptor desensitization and subsequent cellular activity, highlighting its intricate role in modulating cholinergic pathways. | ||||||