AF-DX 384 CAS: 118290-27-0
MF: C27H38N6O2
MW: 478.63
A potent mAChR M2/mAChR M4 selective antagonist.

AF-DX 384 (CAS 118290-27-0)

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Alternate Names: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Application: AF-DX 384 is a potent mAChR M2/mAChR M4 selective antagonist
CAS Number: 118290-27-0
Purity: ≥98%
Molecular Weight: 478.63
Molecular Formula: C27H38N6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

AF-DX 384 is a potent mAChR M2/mAChR M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human mAChR M2/, mAChR M4, mAChR M1, mAChR M3 and mAChR M5 receptors, respectively).


References

1. Miller, J.H., et al. 1991. J. Pharmacol. Exp.T her. 259: 601-607. PMID: 1941609
2. Dopke, K.L., et al. 1995. J. Pharmacol. Exp. Ther. 274: 562-569. PMID: 7616446
3. Grailhe, R., et al. 2009. Brain Res.Bull. 78: 283-289. PMID: 19111597

Physical State :
Solid
Solubility :
Soluble in ethanol (10 mM), and DMSO (50 mM).
Storage :
Store at room temperature
Melting Point :
303.86° C (Predicted)
Boiling Point :
618.39° C at 760 mmHg (Predicted)
Density :
1.15 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
Ki Data :
mAChR M2: Ki= 1 nM (human); mAChR M4: Ki= 2 nM (human); mAChR M1: Ki= 12.4 nM (human); mAChR M5: Ki= 501.19 nM (human)
pK Values :
pKa: 11.55 (Predicted), pKb: 9.8 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
119357
SMILES :
CCCN(CCC)CC1CCCCN1CCNC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4

Download SDS (MSDS)

Certificate of Analysis

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