Molecular structure of AF-DX 384, CAS Number: 118290-27-0
AF-DX 384 (CAS 118290-27-0)
Alternate Names:
N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Application:
AF-DX 384 is a potent mAChR M2/mAChR M4 selective antagonist
CAS Number:
118290-27-0
Purity:
≥98%
Molecular Weight:
478.63
Molecular Formula:
C27H38N6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AF-DX 384 is a potent mAChR M2/mAChR M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human mAChR M2/, mAChR M4, mAChR M1, mAChR M3 and mAChR M5 receptors, respectively).
AF-DX 384 (CAS 118290-27-0) References
- Syntheses of R and S isomers of AF-DX 384, a selective antagonist of muscarinic M2 receptors. | Martin, J., et al. 2000. Bioorg Med Chem. 8: 591-600. PMID: 10732976
- Comparative distribution of binding of the muscarinic receptor ligands pirenzepine, AF-DX 384, (R,R)-I-QNB and (R,S)-I-QNB to human brain. | Piggott, M., et al. 2002. J Chem Neuroanat. 24: 211-23. PMID: 12297267
- Muscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease. | Piggott, MA., et al. 2003. J Chem Neuroanat. 25: 161-73. PMID: 12706204
- Development of a new type of allosteric modulator of muscarinic receptors: hybrids of the antagonist AF-DX 384 and the hexamethonio derivative W84. | Mohr, M., et al. 2004. J Med Chem. 47: 3324-7. PMID: 15163212
- Regional changes in the cholinergic system in mice lacking monoamine oxidase A. | Grailhe, R., et al. 2009. Brain Res Bull. 78: 283-9. PMID: 19111597
- Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors. | Miller, JH., et al. 1991. J Pharmacol Exp Ther. 259: 601-7. PMID: 1941609
- Structure-activity relationships and pharmacological profile of selective tricyclic antimuscarinics. | Eberlein, WG., et al. 1989. Trends Pharmacol Sci. Suppl: 50-4. PMID: 2694523
- Characterization of PCS1055, a novel muscarinic M4 receptor antagonist. | Croy, CH., et al. 2016. Eur J Pharmacol. 782: 70-6. PMID: 27085897
- Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor. | Suno, R., et al. 2018. Nat Chem Biol. 14: 1150-1158. PMID: 30420692
- AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography. | Dopke, KL., et al. 1995. J Pharmacol Exp Ther. 274: 562-9. PMID: 7616446
Inhibitor of:
mAChR M2, and mAChR M4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AF-DX 384, 10 mg | sc-203498 | 10 mg | $129.00 | |||
AF-DX 384, 50 mg | sc-203498A | 50 mg | $548.00 |