Molecular structure of Gallamine Triethiodide, CAS Number: 65-29-2
Gallamine Triethiodide (CAS 65-29-2)
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Alternate Names:
Gallamine Triethiodide is also known as Benzcurine iodide.
Application:
Gallamine Triethiodide is a cardioselective mAChR M2 antagonist, regarded as a neuromuscular blocking agent.
CAS Number:
65-29-2
Purity:
≥95%
Molecular Weight:
891.53
Molecular Formula:
C30H60I3N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Gallamine Triethiodide is an M2 muscarinic antagonist with pronounced cardioselectivity. Gallamine Triethiodide acts by combining with the cholinergic receptor sites in muscle and competitively blocks the transmitter action of acetylcholine. Acetylcholine is a neurotransmitter involved in transmitting signals across the neuromuscular junction. This blockade allows the study of the roles and mechanisms of muscarinic receptors in both central and peripheral nervous systems Gallamine Triethiodide has a parasympatholytic effect on the cardiac vagus nerve.
Gallamine Triethiodide (CAS 65-29-2) References
- Cathodic adsorptive stripping voltammetric determination of muscle relaxant: gallamine triethiodide (flaxedil). | Ali, AM., et al. 2001. J Pharm Biomed Anal. 25: 31-7. PMID: 11274856
- Allosteric antagonists of the muscarinic acetylcholine receptor. | Lee, NH. and el-Fakahany, EE. 1991. Biochem Pharmacol. 42: 199-205. PMID: 1859442
- [Spinal mechanism of the inhibitory effect of somatic input on the cardiac ischemia induced by hypothalamus stimulation]. | Zhu, WJ. and Zhang, RB. 1991. Sheng Li Xue Bao. 43: 141-8. PMID: 2068583
- On the interaction of gallamine with muscarinic receptor subtypes. | Michel, AD., et al. 1990. Eur J Pharmacol. 182: 335-45. PMID: 2397745
- Pharmacologic discrimination between receptor heterogeneity and allosteric interaction: resultant analysis of gallamine and pirenzepine antagonism of muscarinic responses in rat trachea. | Kenakin, T. and Boselli, C. 1989. J Pharmacol Exp Ther. 250: 944-52. PMID: 2778720
- Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat. | Hammer, R., et al. 1986. Life Sci. 38: 1653-62. PMID: 3754610
- Stabilization of antagonist binding to cardiac muscarinic acetylcholine receptors by gallamine and other neuromuscular blocking drugs. | Nedoma, J., et al. 1986. J Pharmacol Exp Ther. 236: 219-23. PMID: 3941394
- Gallamine triethiodide facilitation of local cortical excitability compared with other neuromuscular blocking agents. | Halpern, LM. and Black, RG. 1968. J Pharmacol Exp Ther. 162: 166-73. PMID: 5656595
- Evidence for a central action of gallamine triethiodide (Flaxedil). | Halpern, LM. and Black, RG. 1967. Proc West Pharmacol Soc. 10: 37-8. PMID: 6055501
- Gallamine triethiodide-induced modifications of sodium conductance in Myxicola giant axons. | Schauf, CL. and Smith, KJ. 1982. J Physiol. 323: 157-71. PMID: 6284914
- Blockade of intrafusal neuromuscular junctions of cat muscle spindles with gallamine. | Yamamoto, T., et al. 1994. Exp Physiol. 79: 365-76. PMID: 8074849
- The roles of muscarinic receptor subtypes in modulation of nasal ciliary action. | Yang, B. and McCaffrey, TV. 1996. Rhinology. 34: 136-9. PMID: 8938879
- The inhibitory effect of the neuromuscular blocking agent, gallamine triethiodide, on camel retina acetylcholinesterase activity. | Al-Jafari, AA. 1997. Toxicol Lett. 90: 45-51. PMID: 9020401
Inhibitor of:
AChR, mAChR M, and mAChR M2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gallamine Triethiodide, 1 g | sc-200175 | 1 g | $145.00 | |||
Gallamine Triethiodide, 5 g | sc-200175A | 5 g | $300.00 |