PD 102807 (CAS 23062-91-1)

PD 102807, identified as a highly specific antagonist targeting the mAChR M4 muscarinic receptor, stands out due to its remarkable selectivity in binding interactions. This compound is characterized by its differential inhibition potency across various subtypes of muscarinic acetylcholine receptors (mAChRs), as evidenced by its IC50 values: 91 nM for mAChR M4, 6559 nM for mAChR M1, 3441 nM for mAChR M2, 950 nM for mAChR M3, and 7412 nM for mAChR M5. These values illuminate PD 102807′s pronounced affinity for the M4 receptor over other muscarinic receptor subtypes, showcasing its utility in dissecting the roles and mechanistic actions of M4 receptors in physiological and pathophysiological processes. The specificity of PD 102807 for the M4 subtype provides a critical tool in the investigation of muscarinic receptor pharmacology, enabling researchers to elucidate the distinct functions and signaling pathways mediated by M4 receptors apart from those modulated by M1, M2, M3, and M5 receptors. This selective antagonism is instrumental in advancing our comprehension of the nuanced regulatory roles that muscarinic receptors play in neurotransmission and cellular signaling, thereby enhancing the exploration of targeted interventions in research applications where precise modulation of receptor activity is paramount.