MAB21L2 Activators
MAB21L2 (mab-21-like 2) is a gene that encodes a member of the mab-21 family of proteins, which are involved in early developmental processes and cellular differentiation. The protein encoded by MAB21L2 has been studied primarily for its role in developmental biology, particularly in the development of the eye and the nervous system. MAB21L2 activators are compounds that specifically increase the activity or expression of the MAB21L2 protein. MAB21L2 Activators are molecules that interact with the MAB21L2 protein or its regulatory pathways to enhance its function. These activators work by various mechanisms, such as binding to MAB21L2 and inducing a conformational change that increases its activity, stabilizing the protein to disrupt its degradation, or interacting with transcription factors to upregulate the expression of the MAB21L2 gene. The chemical nature of these activators is diverse, including small molecules, peptides, or other biologically derived compounds that exhibit specificity towards MAB21L2.
Such activators are valuable as biological tools to investigate the role of MAB21L2 in cell biology and embryonic development. By artificially increasing the activity of MAB21L2, researchers can study the downstream effects in cellular models, offering insights into how this gene influences cell fate decisions, organogenesis, and the intricate processes guiding embryonic development. Moreover, understanding the regulation of MAB21L2's activity through such activators could reveal new aspects of gene regulation and protein function within the context of developmental signalling pathways. The study of these activators can expand the current knowledge of the mab-21 protein family and contribute to the broader field of developmental biology by highlighting novel regulatory mechanisms that orchestrate cellular differentiation and morphogenesis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which in turn can activate PKA. PKA phosphorylates various proteins that may be involved in the same developmental processes as MAB21L2, potentially enhancing its downstream effects in cellular differentiation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid binds to retinoic acid receptors (RARs) which act as transcription factors regulating gene expression. MAB21L2 is involved in neural development, and retinoic acid signaling can enhance the differentiation pathways in which MAB21L2 plays a role. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine is known to induce autophagy, a process that can affect cellular differentiation. Since MAB21L2 is important in eye and neural development, spermidine could enhance MAB21L2's role by promoting the autophagic pathways necessary for its function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate substrates involved in various signaling pathways, potentially enhancing the processes that MAB21L2 is involved in, specifically in neuronal cells. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase-4 (PDE4), leading to increased cAMP levels. This elevation can enhance PKA activity, which could positively influence the signaling pathways that MAB21L2 is involved in during eye development. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB 431542 is an inhibitor of the TGF-β receptor. By inhibiting TGF-β signaling, it could lead to the enhancement of alternative signaling pathways, including those where MAB21L2 is a critical player in eye development. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $359.00 $1295.00 | 2 | |
LGK 974 is an inhibitor of Wnt production, which could indirectly enhance pathways MAB21L2 is involved in by reducing signaling through the canonical Wnt pathway, known to be involved in development. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT is a γ-secretase inhibitor that can modulate Notch signaling. Since MAB21L2 is important in neurogenesis, inhibition of Notch may enhance neuronal differentiation processes where MAB21L2 is active. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride can inhibit GSK-3β, leading to activation of Wnt signaling. This may enhance pathways that are synergistic with those regulated by MAB21L2 in developmental processes. | ||||||
all-trans Retinal | 116-31-4 | sc-210778A sc-210778 | 250 mg 1 g | $129.00 $379.00 | 7 | |
All-trans Retinal is an aldehyde form of vitamin A that can be involved in visual cycles and neural development. It may enhance the visual system development pathways where MAB21L2 is implicated | ||||||