Ly-49W Activators
Ly-49W activators encompass a diverse range of compounds that indirectly enhance its activity by modulating various components of the immune system, particularly influencing natural killer (NK) cells. Immunosuppressants like Cyclosporin A and FK506 function by inhibiting calcineurin, thereby reducing IL-2 production and shifting immune responses towards mechanisms involving NK cells, which could enhance the activity of Ly-49W. Similarly, Sirolimus, through mTOR inhibition, redirects immune responses from T-cell proliferation to NK cell-mediated mechanisms. Additionally, compounds such as Brefeldin A and Concanamycin A, by disrupting protein transport and organelle acidification, respectively, impact antigen presentation and T-cell functionality. This alteration in cellular processes indirectly promotes Ly-49W activity through enhanced NK cell surveillance. Furthermore, Monensin and Ionomycin, by affecting cellular ionic gradients and increasing intracellular calcium levels, respectively, modulate processes critical to NK cell function, contributing to the indirect enhancement of Ly-49W.
Continuing this trend, PMA activates protein kinase C (PKC), crucial for regulating NK cell activities, potentially bolstering Ly-49W's role in immune responses. Natural compounds like Curcumin, Resveratrol, and Sulforaphane, known for their broad effects on cellular signaling, also play a role in this enhancement, likely by boosting NK cell activity. Zoledronic acid, while primarily associated with bone metabolism, emerges as a significant contributor due to its immune-modulating properties, particularly in enhancing NK cell cytotoxicity. This enhancement in NK cell function could, in turn, increase the functional activity of Ly-49W. Collectively, these activators form a complex network of pathways that converge to augment the role of Ly-49W in immune surveillance, highlighting the intricate interplay between various immune system components and the functional modulation of specific proteins like Ly-49W.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A, through its immunosuppressive action, inhibits calcineurin, leading to reduced IL-2 production. This shift in the immune response can enhance the activity of Ly-49W by potentially increasing the role of NK cells. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
FK506 inhibits calcineurin by binding to FKBP, decreasing IL-2 and cytokine production. This reduction may indirectly enhance Ly-49W activity in NK cells by reducing T-cell mediated immunity competition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By binding to FKBP12 and inhibiting mTOR, Sirolimus shifts immune responses from T-cell proliferation to other mechanisms, potentially enhancing Ly-49W's role in NK cell-mediated responses. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A inhibits ARF protein's guanine nucleotide exchange, reducing MHC class I molecules on cell surfaces, which can enhance Ly-49W function in NK cells by increasing their response to cells with decreased MHC class I. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $65.00 $162.00 $650.00 $2550.00 | 109 | |
As a vacuolar ATPase inhibitor, Concanamycin A impairs organelle acidification, affecting cytotoxic T-lymphocytes and potentially enhancing NK cells and Ly-49W activity in immune responses. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin disrupts cellular ionic gradients, impacting cytokine secretion and antigen presentation, which could enhance Ly-49W function by affecting the balance between NK cells and other immune cells. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin, a calcium ionophore, increases intracellular calcium levels, which can activate NK cells and indirectly enhance Ly-49W function by stimulating NK cell activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), involved in NK cell regulation, potentially enhancing Ly-49W activity by promoting NK cell-mediated immune responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates various signaling pathways, including those in NK cells. Its influence on NK cell activity could indirectly enhance Ly-49W function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol affects various signaling pathways related to immune responses and could enhance Ly-49W function by modulating NK cell activity. | ||||||