Ly-49T Inhibitors
Ly-49T inhibitors are a class of chemicals that can interfere with the activation and function of the Ly-49T protein. Ly-49T is a killer cell lectin-like receptor that plays a crucial role in the regulation of natural killer (NK) cell activity. It is involved in recognizing and binding to specific ligands on target cells, leading to the activation of NKcells and subsequent target cell killing. The inhibitors mentioned above can directly or indirectly inhibit the function of Ly-49T by targeting various cellular processes and signaling pathways. Tunicamycin inhibits protein glycosylation, disrupting the proper folding and function of Ly-49T. Wortmannin inhibits phosphoinositide 3-kinase (PI3K), disrupting downstream signaling events necessary for Ly-49T activation. Cyclosporin A inhibits calcineurin, disrupting the signaling pathways involved in Ly-49T activation. Rapamycin inhibits mammalian target of rapamycin (mTOR), disrupting the signaling pathways involved in Ly-49T activation and function.
Brefeldin A inhibits protein transport, interfering with the proper localization and function of Ly-49T. Geldanamycin inhibits heat shock protein 90 (Hsp90), disrupting the proper folding and stability of Ly-49T. Staurosporine inhibits protein kinases, including protein kinase C (PKC) and cyclin-dependent kinases (CDKs), disrupting the signaling pathways involved in Ly-49T activation and function. U0126 inhibits mitogen-activated protein kinase kinase (MEK), disrupting downstream signaling events necessary for Ly-49T activation. SB203580 inhibits p38 mitogen-activated protein kinase (MAPK), disrupting the signaling pathways that regulate Ly-49T activation and function. 17-AAG, a derivative of geldanamycin, inhibits Hsp90, disrupting the proper folding and stability of Ly-49T. LY294002 inhibits PI3K, disrupting downstream signaling events necessary for Ly-49T activation. SP600125 inhibits c-Jun N-terminal kinase (JNK), a member of the MAPK family, disrupting the signaling pathways that regulate Ly-49T activation and function. Overall, these inhibitors can directly or indirectly interfere with the activation and function of Ly-49T by targeting various cellular processes and signaling pathways involved in its regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin is an antibiotic that inhibits protein glycosylation by blocking the transfer of N-acetylglucosamine (GlcNAc) to dolichol phosphate, an essential step in the N-linked glycosylation pathway. This disrupts the proper folding and function of Ly-49T. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinase (PI3K), an enzyme involved in signal transduction pathways. By inhibiting PI3K, wortmannin disrupts downstream signaling events necessary for Ly-49T activation and function. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an immunosuppressive drug that inhibits calcineurin, a protein phosphatase involved in T cell activation. By inhibiting calcineurin, cyclosporin A disrupts the signaling pathways involved in Ly-49T activation and function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an immunosuppressive drug that inhibits mammalian target of rapamycin (mTOR), a regulator of cell growth and proliferation. By inhibiting mTOR, rapamycin disrupts the signaling pathways involved in Ly-49T activation and function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is a fungal metabolite that inhibits protein transport from the endoplasmic reticulum (ER) to the Golgi apparatus, disrupting the secretory pathway. This interferes with the proper localization and function of Ly-49T. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin is an antibiotic that inhibits heat shock protein 90 (Hsp90), a molecular chaperone involved in protein folding and stabilization. By inhibiting Hsp90, geldanamycin disrupts the proper folding and stability of Ly-49T. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including protein kinase C (PKC) and cyclin-dependent kinases (CDKs). By inhibiting these kinases, staurosporine disrupts the signaling pathways involved in Ly-49T activation and function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), an enzyme involved in the MAPK signaling pathway. By inhibiting MEK, U0126 disrupts the downstream signaling events necessary for Ly-49T activation and function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 is a specific inhibitor of p38 mitogen-activated protein kinase (MAPK), a signaling molecule involved in cellular stress responses. By inhibiting p38 MAPK, SB203580 disrupts the signaling pathways that regulate Ly-49T activation and function. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG is a derivative of geldanamycin and a potent inhibitor of heat shock protein 90 (Hsp90). By inhibiting Hsp90, 17-AAG disrupts the proper folding and stability of Ly-49T. | ||||||