LRRC9 Activators
LRRC9 Activators encompass a range of chemical compounds that indirectly augment the functional activity of LRRC9 through diverse signaling pathways. Resveratrol and Curcumin, for instance, influence sirtuin and NF-κB pathways, respectively. Resveratrol's activation of SIRT1 leads to widespread deacetylation, altering gene expression in a way that can enhance LRRC9's role in cell signaling and structural organization. Curcumin, by inhibiting NF-κB, affects inflammatory and apoptotic pathways, potentially bolstering LRRC9's function in these processes. Similarly, Sulforaphane and Quercetin, through the activation of Nrf2 and inhibition of PI3K/Akt signaling, respectively, create an environment conducive to LRRC9 activity enhancement, particularly under oxidative stress and altered cell survival dynamics. EGCG's inhibition of protein kinases and Sodium Butyrate's HDAC inhibitory action result in altered gene expression and kinase activity, thereby indirectly supporting LRRC9's function in related pathways.
Further, Retinoic Acid and Lithium Chloride modulate gene expression and Wnt signaling by affecting retinoic acid receptors and inhibiting GSK-3β, respectively. These changes can indirectly enhance LRRC9's role in cell differentiation and proliferation. Forskolin's elevation of cAMP levels and subsequent activation of PKA present another route through which LRRC9's activity can be enhanced, especially in pathways where PKA is a key player. Rapamycin and Metformin, by inhibiting mTOR and activating AMPK, respectively, influence LRRC9's activity in cell growth, stress response, and metabolic regulation pathways. Lastly, Nitric Oxide Donors like Sodium Nitroprusside, by modulating vasodilation and inflammation pathways, potentially enhance LRRC9's function in related cellular signaling processes. Collectively, these LRRC9 Activators, through their targeted effects on various cellular pathways, facilitate the enhancement of LRRC9-mediated functions without necessitating direct activation or upregulation of its expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural phenol, affects sirtuin activity, particularly SIRT1. Activation of SIRT1 leads to deacetylation of various substrates, including transcription factors and histones, altering gene expression patterns. This change can enhance LRRC9's function indirectly by modulating the cellular environment, particularly in pathways related to cell signaling and structural organization. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a biologically active polyphenolic compound, modulates NF-κB signaling. Inhibiting NF-κB alters the expression of genes involved in inflammation and apoptosis. This modulation can indirectly affect LRRC9 activity by influencing pathways related to inflammation, potentially enhancing LRRC9's role in these processes. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, a compound in cruciferous vegetables, activates Nrf2, a key regulator of antioxidant response. By promoting Nrf2-mediated signaling, Sulforaphane enhances cellular antioxidant capacity. This activation indirectly supports LRRC9 function in environments with oxidative stress, potentially enhancing its activity in such conditions. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, inhibits PI3K/Akt signaling. This inhibition can lead to alterations in cellular survival and metabolism pathways, indirectly influencing LRRC9's activity, particularly in pathways where PI3K/Akt signaling is a crucial component. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG), a major component of green tea, inhibits various protein kinases. This broad inhibition can alter multiple signaling pathways, potentially upregulating pathways where LRRC9 is involved, thus indirectly enhancing its activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate, a short-chain fatty acid, acts as a histone deacetylase (HDAC) inhibitor. This action leads to changes in chromatin structure and gene expression. Altered gene expression can indirectly enhance LRRC9 activity by affecting cellular pathways in which LRRC9 is involved, especially those related to gene regulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid, a metabolite of Vitamin A, influences gene expression through retinoic acid receptors. This can lead to changes in cell differentiation and proliferation pathways, indirectly enhancing LRRC9's function in processes where these pathways intersect with LRRC9's role. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride, commonly used in psychiatric treatment, inhibits GSK-3β. This inhibition can lead to alterations in Wnt signaling, indirectly affecting LRRC9's function, especially in pathways where Wnt signaling and GSK-3β activity are important. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, an activator of adenylyl cyclase, increases intracellular cAMP levels. Elevated cAMP can enhance protein kinase A (PKA) activity, indirectly influencing LRRC9 activity by modulating pathways where PKA plays a role, potentially enhancing LRRC9's function in these pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, influences cell growth and proliferation pathways. By inhibiting mTOR, Rapamycin can indirectly enhance LRRC9's activity in pathways where mTOR signaling is significant, particularly in cellular growth and response to stress. | ||||||