LRP4 Activators
The chemical class of LRP4 activators encompasses a diverse array of compounds designed to target specific cellular pathways associated with LRP4 activation. These activators employ a variety of mechanisms to influence crucial pathways, including Wnt, Ras/MAPK, and calcium signaling. Take Calyculin A, for instance, which directly activates LRP4 by inhibiting protein phosphatase 1 (PP1). PP1, a negative regulator of Wnt signaling, is suppressed by Calyculin A, leading to an upregulation of Wnt signaling and subsequent activation of LRP4. Similarly, SB-431542 acts by selectively inhibiting the TGF-β receptor ALK5, indirectly enhancing LRP4 activity through its impact on Wnt signaling. Forskolin, with its activation of adenylate cyclase, contributes to LRP4 activation by positively influencing the PKA pathway-a known regulator of Wnt signaling. The intricate interplay of these activators with specific cellular pathways sheds light on strategies for manipulating LRP4 function in a controlled and targeted manner.
The collective impact of these activators highlights the complex network of signaling pathways that converge on LRP4 regulation. The indirect modulation of LRP4 through pathways like Wnt, Ras/MAPK, and calcium signaling underscores the multifaceted nature of cellular processes involved in finely tuning LRP4 activity. By delving into the nuanced interactions of these chemicals with specific pathways, valuable insights emerge, providing a foundation for developing precise strategies for modulating LRP4 function. This understanding not only broadens our comprehension of cellular signaling intricacies but also opens avenues for innovative approaches in the targeted manipulation of LRP4 activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Calyculin A, a marine toxin, directly activates the LRP4 protein by inhibiting protein phosphatase 1 (PP1). PP1 negatively regulates the Wnt signaling pathway, and its inhibition by Calyculin A enhances Wnt signaling, leading to increased LRP4 activity. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB-431542 acts as an indirect activator of LRP4 by selectively inhibiting the transforming growth factor-beta (TGF-β) receptor ALK5. By suppressing TGF-β signaling, SB-431542 indirectly enhances the Wnt pathway, a known regulator of LRP4, resulting in increased LRP4 activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP levels positively modulate the protein kinase A (PKA) pathway. PKA, in turn, enhances the Wnt pathway, promoting LRP4 activation. Forskolin's indirect influence on Wnt signaling contributes to LRP4 activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 induces calcium influx, activating calcium-dependent signaling pathways. This calcium-dependent activation positively modulates the Ras/MAPK pathway, indirectly influencing LRP4 activity. The elevated Ras/MAPK signaling enhances Wnt pathway activity, contributing to LRP4 activation. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
GSK-3 Inhibitor IX inhibits glycogen synthase kinase-3 (GSK-3), a negative regulator of the Wnt pathway. By blocking GSK-3 activity, this chemical indirectly promotes Wnt signaling, positively affecting LRP4 activation through the enhancement of the Wnt pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits phosphoinositide 3-kinase (PI3K), indirectly affecting the Akt pathway. The modulation of Akt signaling positively influences the Wnt pathway, a known regulator of LRP4, resulting in increased LRP4 activation. LY294002 thus indirectly promotes LRP4 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid influences gene expression through retinoic acid receptors (RARs). It indirectly activates LRP4 by upregulating Wnt signaling, as certain Wnt ligands are direct transcriptional targets of RARs. This leads to enhanced Wnt pathway activity and subsequent LRP4 activation. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB is a store-operated calcium channel (SOCC) inhibitor. By modulating calcium influx, it indirectly influences the Ras/MAPK pathway, positively affecting the Wnt pathway. The resultant increase in Wnt activity contributes to heightened LRP4 activation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits PI3K, indirectly affecting the Akt pathway. The modulation of Akt signaling positively influences the Wnt pathway, a known regulator of LRP4, resulting in increased LRP4 activation. Wortmannin thus indirectly promotes LRP4 activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y27632 is a selective inhibitor of Rho-associated protein kinase (ROCK). Inhibition of ROCK activity indirectly influences LRP4 activation by promoting the Wnt pathway, a downstream target of RhoA/ROCK, leading to increased LRP4 activity. | ||||||