LPPR2 Activators
LPPR2, also known as Lipid Phosphate Phosphatase-Related Protein Type 2 or Phospholipid Phosphatase Related 2 (PLPPR2), is a protein encoded by the LPPR2 gene in humans. It belongs to a family of membrane-associated phosphatases that play a role in the regulation of lipid signaling molecules, particularly phospholipids.LPPR2 is involved in the dephosphorylation of lipid phosphate substrates, such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P). These substrates are bioactive lipids that act as signaling molecules, influencing various cellular processes like cell proliferation, differentiation, migration, and survival. By modulating the levels of these lipid phosphate substrates, LPPR2 plays a role in regulating their signaling pathways.
The enzyme is predominantly expressed in the central nervous system, suggesting a significant role in neural functions. Research indicates that LPPR2 may be involved in the development and maintenance of the nervous system, influencing processes like neurite outgrowth and synaptic function. Its activity in the brain highlights its importance in neural health and disease.LPPR2's role in lipid signaling also suggests its involvement in various pathological conditions, such as cancer, cardiovascular diseases, and neurological disorders. Dysregulation of lipid phosphate signaling pathways can contribute to the development and progression of these diseases.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
While a lipid rather than a traditional chemical, S1P is a key signaling molecule in lipid signaling pathways, potentially influencing LPPR2-related processes. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
FTY720, a sphingosine analogue, impacts sphingosine-1-phosphate receptors, potentially affecting pathways relevant to LPPR2. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $77.00 $316.00 | 12 | |
Ceramide, a central molecule in sphingolipid metabolism, might influence lipid signaling pathways involving LPPR2. | ||||||
β-Estradiol 17-valerate | 979-32-8 | sc-239862 | 1 g | $135.00 | ||
Lisofylline, a synthetic molecule, is known to modulate lipid signaling, potentially impacting LPPR2 functions. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol, while primarily a beta-blocker, has been shown to affect phospholipid metabolism, potentially influencing LPPR2. | ||||||
Miltefosine | 58066-85-6 | sc-203135 | 50 mg | $79.00 | 8 | |
Miltefosine is a phospholipid analogue with effects on lipid signaling pathways, possibly impacting LPPR2 activity. | ||||||
D609 | 83373-60-8 | sc-201403 sc-201403A | 5 mg 25 mg | $185.00 $564.00 | 7 | |
D609 is known to inhibit phosphatidylcholine-specific phospholipase C, potentially affecting lipid signaling pathways involving LPPR2. | ||||||
Myriocin (ISP-1) | 35891-70-4 | sc-201397 | 10 mg | $106.00 | 8 | |
Myriocin is an inhibitor of serine palmitoyltransferase, potentially impacting sphingolipid metabolism and LPPR2 activity. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Simvastatin, a statin, affects lipid metabolism and could indirectly influence LPPR2 activity. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
Perifosine, an alkylphospholipid, can modulate various lipid signaling pathways, potentially affecting LPPR2 functions. | ||||||