LOH11CR1A_AI593442 Inhibitors
LOH11CR1A_AI593442 inhibitors operate through a range of molecular mechanisms to reduce the protein's functional activity. These compounds typically target upstream kinases or signaling pathways that, when inhibited, lead to a downstream reduction in LOH11CR1A_AI593442 activity. For instance, LY294002 and Wortmannin exert their effects by binding to and inhibiting PI3K, which prevents the activation of AKT. Since AKT is a central node in many signaling pathways, its inhibition by these compounds would lead to a decrease in the phosphorylation and activation of numerous downstream proteins, potentially including LOH11CR1A_AI593442. The result is a suppression of cellular processes that are normally promoted by LOH11CR1A_AI593442 when it is active.
Additionally, compounds like PD98059 and U0126 specifically inhibit the activity of MEK, which is a critical kinase in the MAPK/ERK pathway. This pathway is integral to the control of cellular proliferation and differentiation. By blocking MEK with PD98059 or U0126, the activation of ERK1/2 is inhibited, which can lead to a reduction in the transcriptional activation of genes that are regulated by the MAPK/ERK pathway. If LOH11CR1A_AI593442 is one of the proteins that is regulated by this pathway, its activity would be expected to decrease as a result of MEK inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of phosphoinositide 3-kinases (PI3Ks). By inhibiting PI3K, LY294002 prevents the phosphorylation and activation of AKT, which is a downstream effector in the PI3K pathway. As LOH11CR1A_AI593442 is involved in a pathway that is downstream of AKT signaling, the inhibition of AKT phosphorylation leads to reduced activation of LOH11CR1A_AI593442. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of extracellular signal-regulated kinases (ERK1/2) in the MAPK pathway. PD98059 blocks the activation of ERK1/2, therefore inhibiting the signaling cascade that could contribute to the activation of LOH11CR1A_AI593442. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A pyridinyl imidazole compound that selectively inhibits p38 MAP kinase. This inhibition can prevent the kinase activity of p38 MAPK on its substrates, potentially leading to decreased activity of LOH11CR1A_AI593442 if it is a downstream effector of this pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An anthrapyrazolone inhibitor of c-Jun N-terminal kinase (JNK), which interrupts the JNK signaling pathway. By inhibiting JNK, SP600125 would prevent the phosphorylation of transcription factors that could be involved in the functional regulation of LOH11CR1A_AI593442. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A steroidal furan compound that inhibits PI3K irreversibly. Similar to LY294002, wortmannin's inhibition of PI3K results in the blockade of AKT activation, potentially leading to the inhibition of downstream effectors like LOH11CR1A_AI593442. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
A macrolide compound that binds to FKBP12 and inhibits the mammalian target of rapamycin (mTOR). By inhibiting mTOR, rapamycin can suppress the downstream signaling that may involve LOH11CR1A_AI593442, leading to its functional inhibition. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
A selective Src family kinase inhibitor. Src kinases are involved in various signaling pathways, and inhibiting them with PP2 can lead to reduced activity of downstream proteins, potentially including LOH11CR1A_AI593442. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
An inhibitor of MEK1/2, preventing the activation of ERK1/2. U0126 thereby blocks the MAPK/ERK pathway which might be implicated in the functional regulation of LOH11CR1A_AI593442. | ||||||
AG-490 | 133550-30-8 | sc-202046C sc-202046A sc-202046B sc-202046 | 5 mg 50 mg 25 mg 10 mg | $82.00 $323.00 $219.00 $85.00 | 35 | |
A tyrosine kinase inhibitor that targets JAK2. The inhibition of JAK2 can disrupt the JAK/STAT signaling pathway, potentially reducing the activity of downstream proteins like LOH11CR1A_AI593442. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
A multi-targeted inhibitor of several tyrosine kinases including Bcr-Abl and Src family kinases. Dasatinib's broad inhibition of these kinases can diminish multiple signaling pathways, which may include pathways regulating LOH11CR1A_AI593442 activity. | ||||||