LOC90826 Activators
LOC90826 activators comprise a suite of chemical compounds that engage with and amplify specific cellular signaling pathways, which can lead to the activation of LOC90826. Forskolin, Isoproterenol, and Dibutyryl cAMP all function to elevate intracellular cAMP levels, a second messenger that activates protein kinase A (PKA). PKA then phosphorylates various downstream targets, potentially including LOC90826 if it is responsive to cAMP-mediated signaling. This phosphorylation cascade can thus enhance the functional activity of LOC90826. Similarly, Ionomycin and A23187 act as calcium ionophores, increasing the intracellular calcium concentration, which can activate calcium-sensitive proteins and pathways. If LOC90826 is modulated by calcium-dependent signals, these compounds would serve to upregulate its activity.
Cyclin-Dependent Kinase 2 (CDK2) Activators are a diverse set of compounds that interact with the cell cycle machinery to enhance the kinase activity of CDK2. Cyclin A2 and Cyclin E1 directly bind to CDK2, forming complexes that are crucial for the transition through the S phase and for the initiation of DNA replication, respectively. These cyclins trigger conformational changes in CDK2 that increase its substrate phosphorylation capability. Similarly, while initially characterized as inhibitors, compounds like Roscovitine, Olomoucine, Purvalanol A, and Flavopiridol at specific concentrations can paradoxically activate CDK2. They do so by outcompeting inhibitory ATP analogs or by preventing the association of inhibitory proteins with CDK2, thereby indirectly enhancing the phosphorylation of its target proteins, which are essential for cell cycle progression.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. Elevated calcium levels can activate calcium-dependent proteins and signaling pathways that may upregulate LOC90826 activity if it is calcium-responsive. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which phosphorylates a variety of protein targets. If LOC90826 is a substrate of PKC or is involved in PKC-regulated pathways, this would lead to its activation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate activates sphingosine-1-phosphate receptors, which can trigger signaling cascades influencing cell survival and proliferation. If LOC90826 is involved in these pathways, its activity would be enhanced. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can inhibit certain protein kinases and has been shown to modulate signaling pathways. If LOC90826 activity is suppressed by kinases that EGCG inhibits, its activity could be enhanced by this compound. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter the PI3K/Akt pathway. If LOC90826 functions downstream of PI3K or is negatively regulated by Akt, inhibition by LY294002 could enhance LOC90826 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK1/2, leading to a decrease in ERK pathway activity. If ERK negatively regulates LOC90826, then inhibition by U0126 could result in increased activity of LOC90826. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor, leading to an increase in cytosolic calcium levels. Elevated calcium could activate calcium-dependent signaling pathways that may indirectly enhance LOC90826 activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. If protein kinases negatively regulate LOC90826, inhibition by Staurosporine could result in increased activity of LOC90826. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium. If LOC90826 is part of calcium-dependent signaling, its activity would be enhanced by A23187. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl cAMP is a cell-permeable cAMP analog that activates PKA. If LOC90826 is a cAMP/PKA pathway component, its activity would be enhanced by this compound. | ||||||