LOC729730 Inhibitors
Protein kinases play a pivotal role in signal transduction, and inhibitors like Staurosporine and Imatinib can block kinase activity, thus altering signaling cascades. PI3K and mTOR are key nodes in cell growth and survival pathways, and chemicals such as LY294002 and Rapamycin can suppress these pathways, potentially affecting proteins regulated by them. Inhibition of MEK by PD98059, ALK5 by SB431542, and Aurora kinase by ZM-447439 can impact MAPK signaling, TGF-β signaling, and cell cycle progression, respectively.
DNA methylation is crucial for gene expression regulation, and 5-Azacytidine can cause changes in gene expression patterns by inhibiting DNA methyltransferase. Proteasome inhibitors like MG132 can lead to the accumulation of proteins, altering the proteostasis within the cell. QNZ is a transcription factor involved in various cellular processes, and by inhibiting its activation, the transcription of genes related to inflammation and survival can be controlled. JNK signaling is linked to stress responses, and SP600125 can prevent the activity of this pathway, affecting stress-mediated cellular responses. Lastly, energy metabolism is fundamental for cell survival, and inhibitors like 2-Deoxy-D-glucose can disrupt glycolysis, impacting the energy homeostasis within the cell.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent, non-selective inhibitor of protein kinases that can interfere with phosphorylation processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of PI3Ks, can inhibit downstream signaling, including Akt activation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can disrupt protein synthesis and cell growth by interfering with the mTORC1 complex. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
A tyrosine-kinase inhibitor, known to specifically inhibit Bcr-Abl and other tyrosine kinases involved in cell proliferation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A selective inhibitor of MEK1/2, can block MAPK/ERK pathway signaling. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Selectively inhibits the TGF-β type I receptor ALK5, affecting TGF-β signaling and related processes. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
An Aurora kinase inhibitor, can interrupt the cell cycle by interfering with chromosome alignment and segregation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, can cause hypomethylation of DNA and affect gene expression. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor, prevents the degradation of ubiquitinated proteins, affecting cellular protein levels. | ||||||
QNZ | 545380-34-5 | sc-200675 | 1 mg | $115.00 | 12 | |
Specifically inhibits the activation of NF-κB, affecting transcription of target genes involved in inflammation and cell survival. | ||||||