LOC729621 Inhibitors
LOC729621 inhibitors Wortmannin and LY294002, for example, inhibit phosphoinositide 3-kinases (PI3K), a family of enzymes involved in cellular functions such as cell growth and survival. Through inhibiting PI3K, these compounds can alter the phosphorylation status of downstream proteins, potentially including LOC729621, leading to changes in their activity. Similarly, PD98059 and U0126 target the MEK enzyme within the MAPK/ERK pathway, a critical regulator of cell division and differentiation. By inhibiting MEK, these compounds can prevent the activation of the ERK kinase, which may affect LOC729621 if it is a downstream target.
The inhibitors that act on protein degradation pathways, such as Bortezomib and MG132, can affect the stability and turnover of LOC729621. By inhibiting the proteasome, these compounds can lead to the accumulation of proteins within the cell, possibly affecting the degradation rate of LOC729621 and thereby its cellular concentration. Trichostatin A and 5-Azacytidine target epigenetic mechanisms of gene expression regulation. Histone deacetylase and DNA methyltransferase inhibition by these compounds can lead to changes in chromatin structure and DNA methylation, respectively, which can alter the transcription and ultimately the protein levels of LOC729621.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin acts as a PI3K inhibitor, possibly affecting downstream proteins involved in cell survival and growth signaling pathways that may regulate LOC729621. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
As a synthetic molecule, LY294002 inhibits PI3K, which can modulate the Akt pathway, potentially altering the activity of LOC729621 if it is part of this signaling cascade. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor, which can disrupt the MAPK/ERK pathway, possibly influencing LOC729621 activity if it is regulated by this signaling pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAPK, which can affect stress response pathways; if LOC729621 is a stress-responsive protein, its activity may be altered. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor, which can modulate stress signaling pathways, potentially influencing the function of LOC729621 if it is a part of these pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which can affect protein synthesis and cell growth; LOC729621 activity may be altered if it is involved in these processes. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src family kinase inhibitor, which can affect cell adhesion and cytoskeletal dynamics, potentially altering LOC729621 if it interacts with these cellular structures. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits proteasome activity, which can lead to increased protein degradation; LOC729621 may be affected if it is prone to proteasomal degradation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor, which can result in the accumulation of ubiquitinated proteins; LOC729621 may be stabilized or destabilized depending on its ubiquitination state. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylases, which can affect gene expression; LOC729621 may be influenced if it is regulated by acetylation. | ||||||