LOC729465 Inhibitors
LOC729465 Inhibitors such as Wortmannin and LY294002 target the PI3K/Akt pathway, a critical signaling cascade in cell survival and metabolism, which could affect LOC729465 if it is a component or regulator within this pathway. Similarly, compounds like U0126 and PD98059 act on the MAPK/ERK pathway, which is crucial for cell proliferation and differentiation. Their inhibitory action on MEK1/2 could lead to downstream effects on LOC729465 if it is involved in this pathway. Compounds like SB203580 and SP600125 target the stress-activated MAP kinases p38 and JNK, respectively, offering another potential route to modulate LOC729465 activity by altering the response to cellular stress or inflammatory signals.
The mTOR pathway, implicated in cell growth and autophagy, can be modulated by rapamycin, which could impact LOC729465 if it plays a role in these processes. Furthermore, PP2 focuses on Src family tyrosine kinases, which are important for multiple signaling pathways, including those related to cell adhesion, migration, and proliferation. By inhibiting these kinases, PP2 may affect LOC729465 activity. Bortezomib disrupts the ubiquitin-proteasome pathway, which is essential for protein turnover and could potentially lead to altered levels of LOC729465 or its regulatory proteins. Thapsigargin, by inhibiting SERCA, could disrupt intracellular calcium levels, influencing signaling pathways where calcium acts as a secondary messenger; this could extend to pathways involving LOC729465. Lastly, ZM-447439, targeting Aurora kinases involved in cell cycle progression, could indirectly affect LOC729465 if it is linked to cell cycle control.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A steroidal metabolite that acts as a potent and irreversible inhibitor of phosphoinositide 3-kinases (PI3K), which could downregulate signaling pathways where LOC729465 may participate. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
A synthetic nucleoside that inhibits the Akt signaling pathway, potentially reducing the activity of downstream proteins, including LOC729465 if it is an Akt substrate. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A pyridinyl imidazole compound that inhibits p38 MAP kinase, potentially altering the function of proteins like LOC729465 that may be regulated by p38 signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A flavonoid derivative that inhibits PI3K, possibly reducing the activity of proteins in the PI3K/Akt pathway, which could include LOC729465. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
A macrolide compound that binds to FKBP12 and inhibits mTOR, which can suppress the mTOR signaling pathway potentially affecting LOC729465 if it is involved in this pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An inhibitor of MEK, which can block the MAPK/ERK pathway upstream, potentially reducing the activity of proteins like LOC729465 associated with this pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An anthrapyrazolone inhibitor of JNK, which could modulate the activity of proteins involved in the JNK signaling pathway, including possibly LOC729465. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
A selective inhibitor of Src family tyrosine kinases, which could downregulate signaling cascades involving proteins like LOC729465 if they are substrates of Src kinases. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor that can disrupt protein degradation pathways, potentially leading to the accumulation of regulatory proteins that control the function of proteins like LOC729465. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
A sesquiterpene lactone that inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), potentially disturbing calcium signaling related to LOC729465 function. | ||||||