LOC729465 Activators
Forskolin, by stimulating adenylate cyclase, and IBMX, through inhibition of phosphodiesterases, both raise the levels of cyclic nucleotides, cAMP, and cGMP, which are crucial second messengers in cellular signaling. The elevation of these molecules activates protein kinases A and G (PKA and PKG), which can phosphorylate and thus modify the activity of a broad spectrum of proteins. Phorbol esters like PMA are well-known activators of protein kinase C (PKC), which phosphorylates proteins and alters their functions.
Calcium modulators such as Ionomycin, A23187, and Thapsigargin disrupt calcium homeostasis, which is a universal signaling entity, influencing a myriad of calcium-binding proteins and associated kinases and phosphatases. Retinoic Acid and 5-Azacytidine exert their effects at the genomic level, altering gene expression and thereby the synthesis and activity of proteins. Dibutyryl-cAMP serves as a synthetic mimic of cAMP, directly activating PKA, while Sodium Butyrate, by inhibiting histone deacetylases, affects chromatin structure and gene expression. Chloroquine has been found to impact cellular processes such as autophagy, which can have downstream effects on protein activity.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-selective inhibitor of phosphodiesterases, increases cAMP and cGMP by preventing their degradation, which can enhance protein activation via PKA and PKG. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Direct activator of protein kinase C (PKC) which can phosphorylate a broad range of proteins, altering their activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular calcium levels and can activate calcium-dependent proteins, including kinases and phosphatases. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore, raises intracellular calcium levels, potentially modulating the activity of calcium-binding proteins. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to an increase in cytosolic calcium levels which can activate calcium-dependent proteins. | ||||||
PDGFR Tyrosine Kinase Inhibitor IV | 627518-40-5 | sc-205794 sc-205794A sc-205794B sc-205794C | 1 mg 5 mg 10 mg 50 mg | $28.00 $141.00 $262.00 $1150.00 | 2 | |
Although a biological material, it engages PDGF receptors to activate signaling pathways, like MAPK and PI3K, which can indirectly upregulate protein activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Binds to nuclear retinoic acid receptors and can affect gene expression, potentially altering protein synthesis and activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor, changes gene expression patterns, which can result in the activation of proteins. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Cell-permeable cAMP analog that activates PKA, leading to phosphorylation and activation of target proteins. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Histone deacetylase inhibitor that changes gene expression, possibly leading to the increased activity of certain proteins. | ||||||