LOC728867 Activators
Forskolin and IBMX are known to elevate the levels of cyclic nucleotides within the cell, which activate PKA and PKG, respectively. These kinases can phosphorylate a wide range of substrates, resulting in changes to protein activity. PMA and Ionomycin are classic activators of PKC and calcium-dependent proteins, leading to multiple downstream effects on protein function. LY294002 and U0126 provide examples of small molecules that inhibit key kinases within the PI3K/AKT and MAPK/ERK pathways. The inhibition of these kinases can lead to compensatory activation of proteins within these or alternate pathways.
Similarly, SB203580 and SP600125 modulate the activity of p38 MAPK and JNK, respectively, influencing a variety of proteins regulated by these kinases. Y-27632, DAPT, and Rapamycin each target specific components of major signaling pathways – ROCK, Notch, and mTOR, respectively – and can result in the activation of proteins through intricate feedback loops and regulatory mechanisms. Zinc chloride serves as an example of a simple inorganic compound that can have profound effects on protein activity through its role as a cofactor for metalloproteins.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-selective inhibitor of phosphodiesterases, raises intracellular cAMP and cGMP, which can activate protein kinases that modulate protein function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activator of protein kinase C (PKC) which can lead to the phosphorylation and activation of proteins in associated signaling pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular calcium levels, which can activate calcium-dependent protein kinases and subsequent target proteins. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K, leading to altered AKT signaling; this can result in activation of downstream proteins due to feedback loops. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
Inhibits MEK1/2, leading to changes in MAPK/ERK pathway activity, which can activate proteins through compensatory signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibitor of p38 MAPK, can alter signaling and lead to activation of proteins through alternative pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, leading to modulation of AP-1 transcription factor activity, potentially causing activation of certain proteins. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibitor of ROCK kinase, can affect actin cytoskeleton dynamics, potentially leading to the activation of associated proteins. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
Notch signaling pathway inhibitor, can lead to activation of proteins regulated by this pathway through feedback mechanisms. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibitor of mTOR, can activate proteins in related pathways due to the complex interplay of growth factor signaling. | ||||||