LOC665622 Inhibitors
Chemical inhibitors of LOC665622 function by obstructing the protein's interaction with DNA, which is pivotal for its role in chromatin remodeling. These inhibitors, primarily histone deacetylase (HDAC) inhibitors, lead to an increase in the acetylation levels of histone proteins. Compounds such as Trichostatin A, Mocetinostat, Entinostat, Panobinostat, Romidepsin, Vorinostat, Belinostat, Chidamide, Quisinostat, and Givinostat all function by inhibiting HDACs. The inhibition of HDACs results in a less compact chromatin structure, which in turn reduces the binding affinity of chromatin-related proteins like LOC665622 to the DNA. As a consequence, the function of LOC665622 is inhibited, as it relies on the ability to bind to chromatin to exert its effects.
Furthermore, the inhibitor Valproic acid also increases histone acetylation, leading to a relaxed chromatin state that can inhibit LOC665622's DNA binding properties. Similarly, Tacedinaline, a synthetic benzamide derivative, inhibits HDAC, potentially leading to altered chromatin architecture. This alteration further reduces the efficiency with which LOC665622 can interact with chromatin, inhibiting its normal functional role in chromatin remodeling. Each of these chemical inhibitors, by altering the acetylation status of histones and thereby the chromatin structure, can directly inhibit the function of LOC665622, though they do so via mechanisms that are not entirely uniform and may vary in their selectivity and potency against different HDAC enzymes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By inhibiting histone deacetylase, Trichostatin A can increase the acetylation of histones, leading to a less compact chromatin structure and thereby reducing the binding affinity of DNA-binding proteins such as LOC665622 to the DNA, inhibiting its function. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
Mocetinostat is another histone deacetylase inhibitor. Similar to Trichostatin A, Mocetinostat can also lead to hyperacetylation of histones. This process can interfere with the normal function of LOC665622 by altering the chromatin structure and hindering its DNA interaction. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
Entinostat selectively inhibits class I histone deacetylases. By doing so, it can increase acetylation levels of histones, which in turn can obstruct the chromatin-remodeling activities where LOC665622 is involved, thereby inhibiting its function. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
As a pan-deacetylase inhibitor, Panobinostat can broadly increase histone acetylation, which could interfere with chromatin compaction and thus inhibit the function of LOC665622 by preventing its proper binding to chromatin. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin is a cyclic peptide that inhibits histone deacetylase. By this action, it can alter the chromatin structure, which could inhibit the interaction of LOC665622 with DNA, impairing its function. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is an HDAC inhibitor that leads to increased acetylation of histone proteins. This can result in chromatin expansion, which could inhibit the DNA binding capacity of LOC665622, thereby inhibiting its function. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $153.00 $561.00 | ||
Belinostat inhibits several isoforms of histone deacetylase. This inhibition can disrupt the chromatin structure and potentially inhibit the function of LOC665622 by affecting its ability to interact with chromatin. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $61.00 $245.00 $1173.00 | ||
Chidamide is a benzamide chemical that inhibits HDAC, leading to the accumulation of acetylated histones. This can inhibit the function of LOC665622 by changing the chromatin structure, reducing its DNA-binding efficiency. | ||||||
JNJ-26481585 | 875320-29-9 | sc-364515 sc-364515A | 5 mg 50 mg | $321.00 $1224.00 | ||
Quisinostat is a potent HDAC inhibitor. By increasing histone acetylation and altering chromatin architecture, it can inhibit the functional capacity of LOC665622 to bind to DNA. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid, an HDAC inhibitor, can enhance histone acetylation and induce a relaxed chromatin state. This change in chromatin can inhibit the function of LOC665622 by affecting its DNA binding properties. | ||||||