LOC647176 Inhibitors
Wortmannin and LY294002 serve as archetypes of phosphoinositide 3-kinases (PI3K) inhibitors, characterized by their ability to attenuate the PI3K signaling pathway, which is integral to numerous cellular functions, including cell growth and survival. By inhibiting PI3K, these compounds can effectively reduce the activity of proteins like LOC647176 if they are regulated by this pathway. Rapamycin, a well-known inhibitor of the mechanistic target of rapamycin (mTOR), stands out due to its ability to disrupt cell growth and proliferation pathways. The inhibition of mTOR by rapamycin might lead to decreased activity of downstream proteins such as LOC647176 if they are part of the mTOR signaling network. Staurosporine emerges as a non-selective kinase inhibitor, known for its broad activity across a range of kinases. Such an inhibitor can suppress the phosphorylation processes pivotal for the activation or stabilization of proteins, potentially including LOC647176.
In the landscape of MAP kinase signaling modulation, U0126 and SB203580 are notable. U0126 specifically targets MEK1/2, key components of the ERK pathway, while SB203580 is a selective inhibitor of p38 MAP kinase. These inhibitors can indirectly reduce LOC647176 activity if it is influenced by these MAPK pathways. Ibrutinib, another inhibitor targeting a specific kinase, Bruton's tyrosine kinase (BTK), is known to play a significant role in B-cell receptor signaling. By inhibiting BTK, ibrutinib can impede the signaling cascades that might regulate LOC647176. Further addressing the modulation of tyrosine kinases, PP2, as a selective inhibitor of Src family kinases, can undermine the activation of proteins regulated by Src signaling, which includes the potential regulation of LOC647176. Y-27632, which inhibits Rho-associated protein kinase (ROCK), affects cellular processes controlled by ROCK, such as cell shape and motility, and could consequently influence the activity of LOC647176.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A potent PI3K inhibitor that acts by binding irreversibly to the p110 subunit of PI3K, leading to the suppression of the PI3K-AKT signaling pathway which is crucial for many cellular processes. If LOC647176 is a downstream effector of this pathway, this compound would inhibit its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Another PI3K inhibitor which competes with ATP for binding to the catalytic site of PI3K, therefore inhibiting the kinase activity. It blocks the PI3K-AKT pathway and consequently inhibits downstream proteins like LOC647176 if they are regulated by this pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor which binds to FKBP12 and the resulting complex binds to mTOR complex 1 (mTORC1), inhibiting its activity. The inhibition of the mTORC1 can suppress protein synthesis and cell growth, affecting proteins associated with this pathway, possibly including LOC647176. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A broad-spectrum kinase inhibitor that inhibits a wide range of protein kinases. If LOC647176 is phosphorylated as part of its activation or stability, staurosporine can inhibit its function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Specifically inhibits MEK1 and MEK2, leading to the blockade of the MAPK/ERK signal transduction pathway. If LOC647176 is activated by ERK or is part of this pathway, U0126 can inhibit its activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Selectively inhibits p38 MAP kinase. By inhibiting p38 MAPK, SB203580 can affect the activity of proteins regulated by this kinase, potentially including LOC647176. | ||||||
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $153.00 | 5 | |
A BTK inhibitor that irreversibly binds to the cysteine residue at position 481 in BTK. If LOC647176 is part of B-cell receptor signaling or is modulated by BTK, ibrutinib would inhibit its function. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
A selective inhibitor of Src family tyrosine kinases. By inhibiting Src kinases, PP2 can suppress the activation of downstream signaling cascades, which may involve LOC647176. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibits ROCK kinases which are involved in various cellular functions including contraction, motility, proliferation, and apoptosis. If the activity or stability of LOC647176 is regulated by ROCK, Y-27632 would inhibit its function. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
An Aurora kinase inhibitor which prevents the phosphorylation of Aurora A and B, leading to the inhibition of mitotic progression. If LOC647176 plays a role in cell cycle regulation and is modulated by Aurora kinases, ZM-447439 would inhibit its function. | ||||||