LOC646457 Activators
LOC646457 can modulate its activity through various biochemical pathways. Forskolin, Epinephrine, Isoproterenol, and Adenosine all activate adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels within cells. Elevated cAMP is a well-known regulator of protein kinase A (PKA), which, in turn, can activate a wide range of proteins by phosphorylation. In the context of LOC646457, should it be a PKA substrate, the activation of PKA by these chemicals can lead to its phosphorylation and subsequent activity modulation. Another agent, IBMX, functions to prevent the degradation of cAMP by inhibiting phosphodiesterases, thereby sustaining the activation state of PKA and prolonging the phosphorylation signal to LOC646457.
Anisomycin activates stress-activated protein kinases, which can phosphorylate a variety of proteins. If LOC646457 is recognized by these kinases, anisomycin can influence its activity. Capsaicin and Ionomycin increase intracellular calcium levels, which can activate calcium-dependent protein kinases that may target LOC646457 for phosphorylation. Similarly, Thapsigargin disrupts calcium homeostasis by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase, which leads to calcium release from internal stores and activation of downstream kinases that may interact with LOC646457. Phorbol 12-myristate 13-acetate (PMA) directly stimulates protein kinase C (PKC), which phosphorylates a plethora of cellular proteins. If LOC646457 falls within the spectrum of PKC targets, PMA can be a key regulator of its activation state. Lastly, Histamine, through its interaction with histamine receptors, can activate phospholipase C, leading to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). These molecules serve as second messengers that activate PKC, potentially leading to the phosphorylation of LOC646457 if it is within the action radius of PKC.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to adrenergic receptors, which can lead to the activation of adenylyl cyclase and subsequent increase in cAMP levels. This elevation in cAMP may activate PKA, which in turn could activate LOC646457 if it is part of the PKA substrate profile or indirectly through PKA-mediated signaling pathways. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) interacts with its G protein-coupled receptors (GPCRs), leading to the activation of adenylate cyclase and an increase in cAMP. This rise in cAMP could activate PKA that may phosphorylate and activate LOC646457 or alter a signaling cascade that includes LOC646457. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates beta-adrenergic receptors, leading to an increase in cAMP and activation of PKA. If LOC646457 is a part of the cAMP/PKA signaling pathway, this activation could result in the functional activation of LOC646457. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases, enzymes responsible for breaking down cAMP. Its action results in elevated cAMP levels, which could activate PKA, potentially leading to the activation of LOC646457 through phosphorylation or pathway modulation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a pyrrolidine antibiotic that acts as a protein synthesis inhibitor. It activates stress-activated protein kinases (SAPKs), which may lead to the phosphorylation and activation of various proteins, potentially including LOC646457 if it is within the scope of SAPK substrate specificity. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin binds to the transient receptor potential vanilloid 1 (TRPV1), which can lead to an influx of calcium ions. This increase in intracellular calcium can activate various calcium-dependent protein kinases, which could phosphorylate and activate LOC646457 if it is sensitive to calcium-mediated signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a sesquiterpene lactone that inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to an increase in cytosolic calcium levels. Elevated calcium can activate calcium-dependent kinases, which may phosphorylate and activate LOC646457. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activation of PKC can lead to the phosphorylation of specific proteins. If LOC646457 is a target of PKC or is within a pathway regulated by PKC, this activation could lead to the functional activation of LOC646457. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration, potentially activating calcium-dependent kinases. This activation can result in the phosphorylation and functional activation of proteins, including LOC646457 if it is part of the calcium signaling pathway. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine interacts with adenosine receptors, which can activate adenylate cyclase, leading to increased cAMP levels. This can activate PKA, potentially leading to the phosphorylation and activation of LOC646457 if it is regulated by cAMP/PKA signaling. | ||||||