LOC100041434 Inhibitors
LOC100041434 inhibitors operate by suppressing or modifying the activity of specific enzymes or proteins that are central to signaling cascades or cellular functions. For instance, Wortmannin and LY294002 converge on the PI3K/Akt pathway, a crucial axis for cell survival and proliferation, by inhibiting the catalytic function of PI3K, leading to the downstream suppression of Akt signaling. This can alter the activity of any protein that is a part of this pathway or is modulated by it. Similarly, PD0325901 and SB203580 target the MAPK/ERK and p38 MAPK pathways, respectively, which are vital for the regulation of cell division, stress response, and cytokine signaling. Inhibition of these pathways by these compounds can have a broad impact on proteins that are dependent on MAPK signaling for their activation or repression.
Inhibitors such as Ibrutinib and Venetoclax act on specific proteins like Bruton's tyrosine kinase and Bcl-2, respectively, which have wider implications on the B-cell receptor signaling and apoptotic pathways. These pathways are critical for B-cell development and apoptosis regulation, indicating that proteins interacting with or regulated by these pathways can be affected by the inhibitors.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
This PI3K inhibitor suppresses the PI3K/Akt signaling pathway, which regulates cell growth and survival. Inhibition of this pathway can reduce the activity of proteins downstream or upstream of PI3K that are critical for signal transduction. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A selective inhibitor of p38 MAPK, which is involved in the response to stress stimuli and cytokines. It can inhibit the function of proteins that are regulated by p38 MAPK-dependent phosphorylation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which impacts cellular processes such as apoptosis and differentiation. Proteins that rely on JNK signaling for activation or inactivation can be influenced by this compound. | ||||||
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $153.00 | 5 | |
A Bruton's tyrosine kinase inhibitor that affects B-cell receptor signaling. Proteins associated with B-cell development and function can be influenced by this inhibitor. | ||||||
ABT-199 | 1257044-40-8 | sc-472284 sc-472284A sc-472284B sc-472284C sc-472284D | 1 mg 5 mg 10 mg 100 mg 3 g | $116.00 $330.00 $510.00 $816.00 $1632.00 | 10 | |
An inhibitor of the Bcl-2 protein, which is central to the regulation of apoptosis. By inhibiting Bcl-2, it can affect associated proteins that interact with or are regulated by Bcl-2. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
An Aurora kinase inhibitor, affecting cell division by disrupting the function of proteins that are involved in mitosis and regulated by Aurora kinases. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
A Src-family tyrosine kinase inhibitor, which can alter multiple cellular pathways including migration, invasion, and proliferation. Proteins modulated by Src kinases can be influenced. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that prevents the degradation of ubiquitinated proteins, potentially leading to the accumulation and altered function of proteins that undergo proteasomal degradation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Another PI3K inhibitor that suppresses the PI3K/Akt pathway, leading to the modulation of proteins involved in survival and growth signals. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
An inhibitor of NF-kB activation, which impacts transcription and can alter the expression and function of proteins regulated by NF-kB-dependent signaling. | ||||||