LOC100041376 Inhibitors
Inhibitors of LOC100041376 contain Kinase inhibitors such as Wortmannin, SB203580, ZM447439, GW5074, and LY333531 act by binding to the ATP-binding pocket of kinases, thereby preventing the transfer of phosphate groups to substrate molecules. This inhibition can alter signaling cascades that the protein LOC100041376 is part of, resulting in the modulation of its activity.
Proteasome inhibitors like MG132 interfere with the ubiquitin-proteasome pathway, which is responsible for degrading misfolded or damaged proteins. Inhibition of this process can lead to the accumulation of proteins and could affect the stability and function of LOC100041376. Similarly, inhibitors targeting other enzymes involved in post-translational modifications, such as EX-527 which inhibits SIRT1, can change the acetylation status of proteins influencing their function and interaction with other molecules. Inhibitors that target signaling intermediates, such as PD173074 and NSC 23766, disrupt downstream signaling events that could be linked to the regulation or activity of LOC100041376.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent phosphatidylinositol 3-kinase (PI3K) inhibitor that can suppress PI3K-dependent signaling pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase, which can inhibit the p38-dependent signaling pathways involved in inflammation and cell differentiation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can prevent the degradation of proteins, potentially affecting protein turnover and signaling pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), potentially affecting JNK signaling pathways that regulate gene expression and apoptosis. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor that can disrupt mitosis by inhibiting chromosome alignment and segregation. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase (CDK) inhibitor that can arrest the cell cycle by preventing CDK activation. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $47.00 $143.00 $680.00 | 16 | |
PD173074 is a selective inhibitor of the FGFR tyrosine kinase, which can inhibit the FGFR signaling involved in cell growth and angiogenesis. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a c-Raf kinase inhibitor that can disrupt the Raf/MEK/ERK signaling pathway, affecting cell growth and differentiation. | ||||||
LY-333,531 Hydrochloride | 169939-93-9 | sc-364215 sc-364215A | 1 mg 5 mg | $94.00 $287.00 | 6 | |
LY333531 is a selective inhibitor of protein kinase C beta (PKCβ), potentially affecting PKCβ-dependent signaling pathways. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
NSC 23766 is an inhibitor of Rac1 activation, potentially affecting Rac1-mediated signaling pathways involved in cytoskeletal reorganization. | ||||||