LY-333,531 Hydrochloride (CAS 169939-93-9)
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LY-333,531 Hydrochloride is a selective antagonist of the orexin OX1 receptor. It functions by binding to the OX1 receptor and blocking the binding of orexin-A and orexin-B, which are endogenous ligands for the receptor. This interaction inhibits the activation of the OX1 receptor, preventing downstream signaling pathways from being initiated. As a result, LY-333,531 Hydrochloride effectively blocks the excitatory effects of orexin on target cells, leading to a reduction in orexin-mediated physiological responses. Ly-333,531 Hydrochloride′s mechanism of action involves targeting the OX1 receptor and interfering with its normal function, thereby modulating the activity of orexin in experimental applications. By inhibiting the OX1 receptor, LY-333,531 Hydrochloride can be used to investigate the role of orexin signaling in various biological processes.
LY-333,531 Hydrochloride (CAS 169939-93-9) References
- Sodium Butyrate Promotes Reassembly of Tight Junctions in Caco-2 Monolayers Involving Inhibition of MLCK/MLC2 Pathway and Phosphorylation of PKCβ2. | Miao, W., et al. 2016. Int J Mol Sci. 17: PMID: 27735862
- Atorvastatin Inhibited ROS Generation and Increased IL-1β And IL-6 Release by Mononuclear Cells from Diabetic Patients. | Dos Anjos, PMF., et al. 2019. Endocr Metab Immune Disord Drug Targets. 19: 1207-1215. PMID: 31416412
- Retinal Delivery of the Protein Kinase C-β Inhibitor Ruboxistaurin Using Non-Invasive Nanoparticles of Polyamidoamine Dendrimers. | Alshammari, RA., et al. 2022. Pharmaceutics. 14: PMID: 35890338
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY-333,531 Hydrochloride, 1 mg | sc-364215 | 1 mg | $94.00 | |||
LY-333,531 Hydrochloride, 5 mg | sc-364215A | 5 mg | $287.00 |