LY-333,531 Hydrochloride CAS: 169939-93-9
MF: C28H28N4O3•HCl
MW: 505.10
A selective PKC inhibitor with potential anticancer activity.

LY-333,531 Hydrochloride (CAS 169939-93-9)

LY-333,531 Hydrochloride | CAS 169939-93-9 is rated 4.5 out of 5 by 2.
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Synonym: Ruboxistaurin hydrochloride
Application: A selective PKC inhibitor with potential anticancer activity
CAS Number: 169939-93-9
Purity: ≥98%
Molecular Weight: 505.10
Molecular Formula: C28H28N4O3•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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LY-333,531 Hydrochloride is a potent, selective inhibitor of Protein Kinase C isozymes, PKC beta I (IC50 = 4.7 nM) and PKC beta II (IC50 = 5.9 nM). It is potentially beneficial for cancer research.

Physical State :
Solid
Solubility :
Soluble in water (slightly), DMSO, and 100% ethanol (slightly).
Storage :
Store at -20° C
Refractive Index :
n20D ~1.70 (Predicted)
IC50 :
PKC beta II : IC50 = 5.9 nM; PKC beta I: IC50 = 4.7 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9870785
Merck Index :
14: 8290
MDL Number :
MFCD08702685
SMILES :
CN(C)C[[email protected]@H]1CCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=O.Cl

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Certificate of Analysis

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LY-333,531 Hydrochloride  Product Citations

See how others have used LY-333,531 Hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 27543462  Sulen, A. et al. 2016. Pharmacol. Res. 113: 216-227.

PMID: # 26302339  Wong, TY. et al. 2015. PLoS ONE. 10: e0135637.

PMID: # 23770211  Wang, Z. et al. 2013. Life sciences. 93: 116-24.

Citations 1 to 3 of 3 total
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Rated 4 out of 5 by from great inhibitor This inhibitor can successfully suppress Protein Kinase C isoforms
Date published: 2016-11-01
Rated 5 out of 5 by from Snow Snow, JB. et al. (PubMed 21803871) used LY-333,531, a PKC inhibitor, to investigate the role of PKC in enhanced endothelin-1-induced (ET-1) pulmonary vasoconstrictor reactivity following intermittent hypoxia (IH). They concluded that eucapnic-IH augments pulmonary vasoconstrictor reactivity to ET-1 through a novel PKC -dependent mechanism that is independent of altered PKC expression. -SCBT Publication Review
Date published: 2015-06-18
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