The chemical class designated as LOC100040781 Inhibitors encompasses a series of specialized compounds designed to inhibit the activity of the gene product expressed by LOC100040781. This gene, identified through in-depth genomic analysis, has been recognized for its role in various cellular processes and functions. The expression and function of LOC100040781 are highly dependent on the specific cellular context and are influenced by various external environmental factors. Inhibitors targeting this gene have been meticulously developed to selectively bind to the proteins or enzymes that are the result of LOC100040781 expression. This selective binding is crucial, as it allows these inhibitors to directly impact the biochemical pathways involving the LOC100040781 gene product. By modulating the activity of this gene product, these inhibitors aim to alter the associated cellular processes, thereby influencing specific cellular functions and mechanisms.
The development of LOC100040781 Inhibitors is a complex and multifaceted task that involves integrating principles from molecular biology, chemistry, and bioinformatics. The process begins with a comprehensive understanding of the structural and functional aspects of the LOC100040781 gene product. Techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and computational molecular modeling are employed to gain detailed insights into the target molecule. This foundational knowledge is essential for the rational design of inhibitors that are both effective in their interaction and highly selective for their target. Typically, these inhibitors are small molecules, crafted for efficient penetration into cellular membranes and for establishing a stable and effective interaction with their target. The molecular design of these inhibitors is carefully optimized to ensure robust interactions with the target molecule, often involving hydrogen bonds, hydrophobic interactions, and van der Waals forces. The efficacy of these inhibitors is rigorously tested through various biochemical assays in vitro. These assays are critical for determining the potency, specificity, and overall behavior of the inhibitors in controlled experimental conditions. Such studies provide essential insights into the inhibitors' mechanism of action and interaction dynamics, paving the way for further research into their potential impact on cellular pathways and functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat inhibits histone deacetylases, which could lead to changes in chromatin structure and potentially downregulate gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor could lead to DNA demethylation and potentially affect gene expression patterns. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Similar to 5-Azacytidine, decitabine could induce DNA demethylation and alter gene expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
As a histone deacetylase inhibitor, entinostat may modify chromatin and influence gene transcription. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 may inhibit DNA methyltransferases, potentially affecting methylation status and gene expression. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 free base | sc-202651 | 5 mg | $148.00 | 4 | |
This inhibitor of histone methyltransferase G9a may alter histone methylation and affect gene expression. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 inhibits BET bromodomain proteins, potentially impacting the transcription of certain genes. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
Mocetinostat is a histone deacetylase inhibitor that might modify chromatin structure and influence gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This compound is a histone deacetylase inhibitor that can alter chromatin structure and affect gene transcription. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
Zebularine is a cytidine analog that can be incorporated into DNA and inhibit DNA methylation, affecting gene expression. | ||||||