LIPN Activators
LIPN Activators are a class of compounds that enhance the function of LIPN by directly or indirectly influencing the specific signaling pathways or biological processes that it is involved in. These activators include compounds like Cyclosporin A, Forskolin, and PMA which influence the functional activity of LIPN through the calcineurin-NFAT pathway, cAMP-PKA pathway, and PKC pathway respectively. For example, Cyclosporin A maintains NFAT in a phosphorylated state, enabling its interaction with LIPN in the nucleus to enhance LIPN's functional activity. Similarly, Forskolin enhances cAMP production leading to PKA activation, which in turn phosphorylates LIPN, enhancing its functional activity. PMA, on the other hand, enhances LIPN's functional activity through PKC activation, which phosphorylates LIPN.
LIPN Activators also include compounds like Rapamycin, Roscovitine, Paclitaxel, Vinblastine, Okadaic Acid, LY294002, Wortmannin, PD98059, and SB203580, which influence the functional activity of LIPN through modulation of protein synthesis, cell cycle progression, and protein phosphorylation. For instance, Rapamycin inhibits mTOR complex 1, reducing overall protein synthesis, but enhancing LIPN'sfunctional activity by reducing competition in protein synthesis. Roscovitine, Paclitaxel, and Vinblastine enhance LIPN's functional activity by halting the cell cycle or cell division, thereby allowing LIPN to function without interference. Okadaic Acid increases the number of phosphorylated proteins, including LIPN, thereby enhancing its functional activity. LY294002, Wortmannin, PD98059, and SB203580 enhance LIPN's functional activity by reducing inhibitory signaling through the PI3K-Akt pathway and ERK pathway, thereby decreasing the inhibition of protein synthesis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A inhibits the protein phosphatase, calcineurin. This inhibition leads to an increased concentration of phosphorylated NFAT in the cytoplasm, preventing its translocation to the nucleus. LIPN, a nuclear protein, interacts with NFAT in the nucleus to enhance its functional activity. Therefore, Cyclosporin A indirectly enhances the functional activity of LIPN by maintaining NFAT in a state that readily interacts with LIPN. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR complex 1, leading to a reduction in protein synthesis. However, LIPN, being a nuclear protein, can still be synthesized and translocate to the nucleus. In the absence of mTOR complex 1 activity, LIPN's functional activity is enhanced due to less competition in protein synthesis. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin enhances the production of cAMP by activating adenylyl cyclase. Increased cAMP levels lead to PKA activation which can phosphorylate LIPN. Phosphorylated LIPN has enhanced functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC). PKC can phosphorylate LIPN, enhancing its functional activity. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a cyclin-dependent kinase inhibitor that halts the cell cycle. With the cell cycle paused, nuclear proteins like LIPN can enhance their functional activity without the interference of cell cycle progression. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules, halting cell division. This halt allows nuclear proteins like LIPN to enhance their functional activity without the interference of cell division. | ||||||
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $107.00 $404.00 $550.00 $2200.00 | 9 | |
Vinblastine disrupts microtubule formation, halting cell division. This halt allows nuclear proteins like LIPN to enhance their functional activity without the interference of cell division. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to an increase in the number of phosphorylated proteins. Phosphorylated LIPN has enhanced functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, leading to a reduction in Akt signaling. With reduced Akt signaling, there is less inhibition of protein synthesis, allowing for enhanced functional activity of LIPN. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits PI3K, leading to a reduction in Akt signaling. With reduced Akt signaling, there is less inhibition of protein synthesis, allowing for enhanced functional activity of LIPN. | ||||||