Lingo-2 Inhibitors
Chemical inhibitors of Lingo-2 can affect various signaling pathways in which this protein is involved, each inhibitor targeting specific molecules that contribute to the functional activity of Lingo-2. LY294002, for instance, targets phosphoinositide 3-kinases (PI3K), essential components in pathways related to neuron survival and differentiation. By inhibiting PI3K, LY294002 disrupts AKT phosphorylation, a key process in survival signaling, thereby dampening Lingo-2's role in neuron health. Similarly, U0126 and PD98059 are both inhibitors of MEK1/2, which are upstream regulators of ERK in the MAPK/ERK pathway. By preventing ERK activation, these inhibitors interfere with downstream signaling, which is crucial for the effects mediated by Lingo-2 on neuronal survival and axonal growth. SB203580 and Y-27632, which selectively inhibit p38 MAP kinase and ROCK respectively, also contribute to the functional inhibition of Lingo-2 by reducing signaling through pathways that affect neural function, health, and neurite outgrowth.
The modulation of other enzymes and signaling molecules can further influence the function of Lingo-2. For example, SP600125 inhibits c-Jun N-terminal kinase (JNK), which is implicated in neuronal apoptosis and regeneration, processes in which Lingo-2 participates. GM6001, by inhibiting matrix metalloproteases (MMPs), reduces the processing of molecules that regulate Lingo-2 activity, thus affecting its role in neural pathways. Additionally, NSC23766, by inhibiting the small GTPase Rac1, affects the reorganization of the actin cytoskeleton, an essential process in growth cone collapse and axon guidance where Lingo-2 is known to be involved. BAPTA-AM, an intracellular calcium chelator, disrupts calcium-dependent signaling pathways, indirectly affecting the signaling in which Lingo-2 is engaged. Finally, Go6976 and PP2 target Protein Kinase C and Src family kinases, respectively, which are involved in cellular processes such as cytoskeletal organization and cell adhesion, thereby influencing the regulatory role of Lingo-2 in these processes. Each inhibitor, through its specific target, contributes to the modulation of Lingo-2's function in neural cell signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
This chemical is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in signaling pathways that can regulate growth factor receptor-mediated effects on neuronal differentiation and survival, pathways Lingo-2 may be involved in. Inhibition of PI3K can lead to reduced AKT phosphorylation, a process that could diminish the survival signaling, potentially inhibiting the functionality of Lingo-2 in neuron survival and regeneration. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which are upstream of ERK in the MAPK/ERK pathway. Lingo-2 is implicated in neuronal signaling pathways, and inhibition of MEK1/2 can prevent ERK activation. This results in inhibition of the downstream signaling that could be crucial for Lingo-2 mediated effects on neuronal survival and axonal growth. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 selectively inhibits p38 MAP kinase, which is involved in signaling pathways that affect neural function and health. Inhibition of p38 MAP kinase leads to decreased signaling through pathways that Lingo-2 may influence, possibly reducing the protein's ability to mediate effects on neuronal survival and repair mechanisms. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which plays a role in neuronal apoptosis and regeneration. Inhibition of JNK can disrupt signaling needed for Lingo-2 to exert its effects on neurons, leading to functional inhibition of Lingo-2 in its role in neurodegenerative processes. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
DAPT is a gamma-secretase inhibitor, which can prevent the cleavage of proteins that are part of signaling pathways interacting with Lingo-2. By inhibiting gamma-secretase, DAPT can disrupt the Notch signaling pathway, potentially inhibiting Lingo-2's functional role in neurogenesis and oligodendrocyte function. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $75.00 $265.00 | 55 | |
GM6001 is a broad-spectrum matrix metalloprotease (MMP) inhibitor. MMPs can process a wide range of molecules including growth factors and receptors that may regulate Lingo-2 activity. By inhibiting MMPs, GM6001 can reduce the processing of molecules involved in pathways where Lingo-2 has a functional role, leading to its inhibition. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is an intracellular calcium chelator. Calcium signaling is essential for numerous neuronal processes, and Lingo-2 is associated with the regulation of neuronal survival and axon guidance, which are calcium-dependent. By chelating intracellular calcium, BAPTA-AM can inhibit calcium-dependent signaling pathways in which Lingo-2 is functionally involved. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which prevents the activation of ERK. Since Lingo-2 can be implicated in pathways associated with neuronal differentiation and myelination mediated by ERK signaling, its inhibition through PD98059 can lead to functional inhibition of Lingo-2 in these pathways. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor, which can impede the RhoA/ROCK pathway. Since Lingo-2 has been implicated in RhoA/ROCK-mediated negative regulation of neurite outgrowth, inhibition of ROCK can disrupt this signaling, leading to functional inhibition of Lingo-2 in neurite outgrowth. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
Go6976 is a potent inhibitor of Protein Kinase C (PKC). PKC is involved in signaling pathways that can regulate cytoskeletal organization and cell adhesion, processes that are crucial for the neuronal functions where Lingo-2 is involved. Inhibiting PKC could disrupt these processes and thus inhibit the function of Lingo-2. | ||||||