Lingo-2 Activators
LINGO-2 Activators consist of a variety of compounds that indirectly enhance the functional activity of LINGO-2, mainly through pathways associated with neuronal development, survival, and differentiation. Growth factors like Brain-Derived Neurotrophic Factor (BDNF), Insulin-like Growth Factor 1 (IGF-1), Ciliary Neurotrophic Factor (CNTF), and Glial cell line-Derived Neurotrophic Factor (GDNF) play pivotal roles in this enhancement. BDNF promotes neuronal survival and differentiation, indirectly impacting pathways where LINGO-2 is involved. Similarly, IGF-1's influence on neurodevelopment and axonal growth, and CNTF and GDNF's modulation of neuronal survival and axon growth pathways, indirectly enhance LINGO-2 activity, given its regulatory role in these processes. Nerve Growth Factor (NGF) and Erythropoietin (EPO) also contribute, with NGF focusing on neuronal survival and differentiation, and EPO on neuroprotection, both affecting signaling pathways intersecting with those regulated by LINGO-2.
Additionally, factors like Platelet-Derived Growth Factor (PDGF) and Vascular Endothelial Growth Factor (VEGF) indirectly augment LINGO-2 activity by modulating cell growth, survival, angiogenesis, and neurogenesis pathways. These pathways are crucial to the roles played by LINGO-2 in the nervous system. Sphingosine-1-phosphate (S1P), a bioactive lipid, and Forskolin, through its cAMP-elevating action, further influence pathways involved in neuronal survival and differentiation, thereby enhancing LINGO-2 activity. Retinoic Acid, known for its role in neuronal differentiation, indirectly impacts LINGO-2-involved pathways. Lastly, 7,8-Dihydroxyflavone, a TrkB agonist, activates TrkB receptors, influencing pathways in which LINGO-2 is engaged, particularly in neuronal survival and differentiation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Buthionine sulfoximine | 83730-53-4 | sc-200824 sc-200824A sc-200824B sc-200824C | 500 mg 1 g 5 g 10 g | $286.00 $442.00 $1532.00 $2975.00 | 26 | |
NGF, critical for neuronal survival and differentiation, indirectly enhances LINGO-2 activity. It modulates signaling pathways that intersect with those regulated by LINGO-2. | ||||||
Bis(pinacolato)diboron | 73183-34-3 | sc-252467 sc-252467A | 1 g 5 g | $44.00 $82.00 | ||
PDGF indirectly enhances LINGO-2 activity by modulating cell growth and survival signaling pathways, which intersect with those involving LINGO-2. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P, a bioactive lipid, indirectly enhances LINGO-2 activity by modulating signaling pathways involved in neuronal survival and differentiation, where LINGO-2 is engaged. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, by elevating cAMP levels, indirectly enhances LINGO-2 activity. It affects signaling pathways related to neuronal development and function, where LINGO-2 is involved. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid indirectly enhances LINGO-2 activity by influencing neuronal differentiation pathways. LINGO-2 plays a role in these pathways, particularly in neurodevelopment. | ||||||
7,8-Dihydroxyflavone | 38183-03-8 | sc-278634 | 100 mg | $52.00 | 2 | |
7,8-Dihydroxyflavone, a TrkB agonist, indirectly enhances LINGO-2 activity by activating TrkB receptors. This activation influences pathways involving LINGO-2, especially in neuronal survival and differentiation. | ||||||