LIMP II Activators
Chemicals classified as LIMP II Activators can be understood to operate by modulating cellular pathways that affect lysosomal biogenesis, function, or protein trafficking, thereby indirectly affecting the expression or activity of LIMP II. These chemicals either bind to nuclear receptors like all-trans retinoic acid binding to retinoid receptors or interact with cellular enzymes and signaling molecules, leading to transcriptional changes. For example, forskolin activates adenylate cyclase, thereby increasing cAMP levels, which can influence lysosomal enzyme trafficking.
Moreover, the stress response induced by agents like β-lapachone, which raises reactive oxygen species levels, may activate signaling pathways that upregulate lysosomal components, including LIMP II, to maintain cellular homeostasis. Lipid metabolism modulators such as clofibrate and mevastatin influence peroxisome proliferator-activated receptors and cholesterol biosynthesis pathways, respectively, which could necessitate enhanced lysosomal activity and thus potentially augment the expression of lysosomal proteins such as LIMP II.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A metabolite of Vitamin A that can regulate gene expression by activating nuclear retinoid receptors, leading to lysosomal biogenesis and possibly enhancing LIMP II expression. | ||||||
25-Hydroxycholesterol | 2140-46-7 | sc-214091B sc-214091 sc-214091A sc-214091C | 5 mg 10 mg 25 mg 100 mg | $52.00 $89.00 $166.00 $465.00 | 8 | |
A cholesterol derivative that can induce lysosomal biogenesis via liver X receptors (LXR), which may increase the expression of LIMP II as part of the lysosomal response. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
An adenylate cyclase activator that raises intracellular cAMP levels, possibly leading to enhanced lysosomal enzyme trafficking and increased levels of LIMP II in lysosomes. | ||||||
β-Lapachone | 4707-32-8 | sc-200875 sc-200875A | 5 mg 25 mg | $110.00 $450.00 | 8 | |
A compound that can increase cellular reactive oxygen species, potentially inducing a compensatory response that includes the upregulation of lysosomal components such as LIMP II. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
A PPARα agonist that can lead to upregulation of lipid metabolism pathways, which may require increased lysosomal activity and potentially higher expression of LIMP II. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $50.00 $70.00 $195.00 | 11 | |
An inhibitor of Syk kinase that can modulate signaling pathways associated with cellular stress and potentially enhance lysosomal function and LIMP II levels. | ||||||
Mevastatin (Compactin) | 73573-88-3 | sc-200853 sc-200853A | 10 mg 50 mg | $75.00 $175.00 | 18 | |
An HMG-CoA reductase inhibitor that can influence cholesterol biosynthesis and indirectly impact lysosomal function and LIMP II expression. | ||||||
2-Hydroxypropyl-β-cyclodextrin | 128446-35-5 | sc-203461 sc-203461B sc-203461C sc-203461A | 1 g 100 g 500 g 5 g | $52.00 $620.00 $1950.00 $130.00 | 8 | |
A compound that depletes cholesterol from cell membranes, potentially causing a compensatory increase in lysosomal biogenesis and LIMP II expression. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
A V-ATPase inhibitor that raises lysosomal pH, potentially triggering an adaptive response that can include the upregulation of lysosomal proteins like LIMP II. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
As a secondary messenger, it can activate PKA and other pathways, potentially leading to changes in gene expression and an increase in lysosomal proteins including LIMP II. | ||||||